{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["732"],"submitter":["Murphy EJ"],"funding":["Health Research Board"],"pubmed_abstract":["Coronavirus pneumonia is accompanied by rapid virus replication, where a large number of inflammatory cell infiltration and cytokine storm may lead to acute lung injury, acute respiratory distress syndrome (ARDS) and death. The uncontrolled release of pro-inflammatory cytokines, including interleukin (IL)-1β and IL-6, is associated with ARDS. This constituted the first study to report on the variability in physicochemical properties of β-glucans extracts from the same edible mushroom Lentinus edodes on the reduction of these pro-inflammatory cytokines and oxidative stress. Specifically, the impact on the immunomodulatory and cytoprotective properties of our novel in 'house' (IH-Lentinan, IHL) and a commercial (Carbosynth-Lentinan, CL) Lentinan extract were investigated using in vitro model"],"journal":["The Science of the total environment"],"pagination":["139330"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7211630"],"repository":["biostudies-literature"],"pubmed_title":["β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects - Implications for coronavirus disease (COVID-19) immunotherapies."],"pmcid":["PMC7211630"],"pubmed_authors":["Lynch M","Laffey JG","Masterson C","O'Toole D","Murphy EJ","Stack GD","Rowan NJ","Rezoagli E","Major I"],"additional_accession":[]},"is_claimable":false,"name":"β-Glucan extracts from the same edible shiitake mushroom Lentinus edodes produce differential in-vitro immunomodulatory and pulmonary cytoprotective effects - Implications for coronavirus disease (COVID-19) immunotherapies.","description":"Coronavirus pneumonia is accompanied by rapid virus replication, where a large number of inflammatory cell infiltration and cytokine storm may lead to acute lung injury, acute respiratory distress syndrome (ARDS) and death. The uncontrolled release of pro-inflammatory cytokines, including interleukin (IL)-1β and IL-6, is associated with ARDS. This constituted the first study to report on the variability in physicochemical properties of β-glucans extracts from the same edible mushroom Lentinus edodes on the reduction of these pro-inflammatory cytokines and oxidative stress. Specifically, the impact on the immunomodulatory and cytoprotective properties of our novel in 'house' (IH-Lentinan, IHL) and a commercial (Carbosynth-Lentinan, CL) Lentinan extract were investigated using in vitro model","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Aug","modification":"2026-05-02T05:07:19.865Z","creation":"2020-06-09T07:04:41Z"},"accession":"S-EPMC7211630","cross_references":{"pubmed":["32413619"],"doi":["10.1016/j.scitotenv.2020.139330"]}}