{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gruhn JR"],"funding":["Carlsbergfondet","Rosetrees Trust","European Research Council","Medical Research Council","Novo Nordisk Fonden","Danish National Research Foundation","NIGMS NIH HHS"],"pagination":["1466-1469"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7212007"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["365(6460)"],"pubmed_abstract":["Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans."],"journal":["Science (New York, N.Y.)"],"pubmed_title":["Chromosome errors in human eggs shape natural fertility over reproductive life span."],"pmcid":["PMC7212007"],"funding_grant_id":["M442","724718","MR/M000664/1","NNF15OC0016662","R35 GM133747","337415"],"pubmed_authors":["Newnham LJ","Hoffmann ER","Blanshard R","Liss J","Ubaldi F","Capalbo A","Chan AC","Gruhn JR","Colmorn LB","Scarica C","Nikiforov D","Taylor D","Hartshorne G","Bjorn AB","Krapchev M","Grondahl ML","Ernst E","Cheng J","Elder K","Vogel I","Andersen CY","Kristensen SG","Shukla V","Zielinska AP","Cimadomo D","Rienzi L","Blayney M","McCoy R","Schuh M","Lukaszuk K"],"additional_accession":[]},"is_claimable":false,"name":"Chromosome errors in human eggs shape natural fertility over reproductive life span.","description":"Chromosome errors, or aneuploidy, affect an exceptionally high number of human conceptions, causing pregnancy loss and congenital disorders. Here, we have followed chromosome segregation in human oocytes from females aged 9 to 43 years and report that aneuploidy follows a U-curve. Specific segregation error types show different age dependencies, providing a quantitative explanation for the U-curve. Whole-chromosome nondisjunction events are preferentially associated with increased aneuploidy in young girls, whereas centromeric and more extensive cohesion loss limit fertility as women age. Our findings suggest that chromosomal errors originating in oocytes determine the curve of natural fertility in humans.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Sep","modification":"2025-04-22T21:20:41.243Z","creation":"2020-10-29T15:27:43Z"},"accession":"S-EPMC7212007","cross_references":{"pubmed":["31604276"],"doi":["10.1126/science.aav7321"]}}