{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["De Pasquale D"],"funding":["European Research Council","Horizon 2020"],"pagination":["108742"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7212088"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["192"],"pubmed_abstract":["Glioblastoma multiforme (GBM) is one of the most aggressive types of brain cancer, characterized by rapid progression, resistance to treatments, and low survival rates; the development of a targeted treatment for this disease is still today an unattained objective. Among the different strategies developed in the latest few years for the targeted delivery of nanotherapeutics, homotypic membrane-membrane recognition is one of the most promising and efficient. In this work, we present an innovative drug-loaded nanocarrier with improved targeting properties based on the homotypic recognition of GBM cells. The developed nanoplatform consists of boron nitride nanotubes (BNNTs) loaded with doxorubicin (Dox) and coated with cell membranes (CM) extracted from GBM cells (Dox-CM-BNNTs). We demonstrat"],"journal":["Materials & design"],"pubmed_title":["Homotypic targeting and drug delivery in glioblastoma cells through cell membrane-coated boron nitride nanotubes."],"pmcid":["PMC7212088"],"funding_grant_id":["709613"],"pubmed_authors":["Tapeinos C","Lauciello S","De Pasquale D","Finamore F","Rocchiccioli S","Larranaga A","Prato M","Michelucci E","McDonnell L","Scarpellini A","Drago F","Ciofani G","Marino A","Pucci C"],"additional_accession":[]},"is_claimable":false,"name":"Homotypic targeting and drug delivery in glioblastoma cells through cell membrane-coated boron nitride nanotubes.","description":"Glioblastoma multiforme (GBM) is one of the most aggressive types of brain cancer, characterized by rapid progression, resistance to treatments, and low survival rates; the development of a targeted treatment for this disease is still today an unattained objective. Among the different strategies developed in the latest few years for the targeted delivery of nanotherapeutics, homotypic membrane-membrane recognition is one of the most promising and efficient. In this work, we present an innovative drug-loaded nanocarrier with improved targeting properties based on the homotypic recognition of GBM cells. The developed nanoplatform consists of boron nitride nanotubes (BNNTs) loaded with doxorubicin (Dox) and coated with cell membranes (CM) extracted from GBM cells (Dox-CM-BNNTs). We demonstrat","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jul","modification":"2025-04-04T08:48:28.757Z","creation":"2020-07-04T07:19:21Z"},"accession":"S-EPMC7212088","cross_references":{"pubmed":["32394995"],"doi":["10.1016/j.matdes.2020.108742"]}}