{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26"],"submitter":["Bao N"],"pubmed_abstract":["<h4>Background</h4>Conopeptides are neuropharmacological peptides derived from the venomous salivary glands of cone snails. Among 29 superfamilies based on conserved signal sequences, T-superfamily conotoxins, which belong to the smallest group, include four different frameworks that contain four cysteines denominated I, V, X and XVI. In this work, the primary structure and the cysteine connectivity of novel conotoxin of <i>Conus bandanus</i> were determined by tandem mass spectrometry using collision-induced dissociation.<h4>Methods</h4>The venom glands of <i>C. bandanus</i> snails were dissected, pooled, and extracted with 0.1% trifluoroacetic acid in three steps and lyophilized. The venom was fractionated and purified in an HPLC system with an analytical reversed-phase C<sub>18</sub> co"],"journal":["The journal of venomous animals and toxins including tropical diseases"],"pagination":["e20190095"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7216822"],"repository":["biostudies-literature"],"pubmed_title":["Isolation and structural identification of a new T1-conotoxin with unique disulfide connectivities derived from <i>Conus bandanus</i>."],"pmcid":["PMC7216822"],"pubmed_authors":["Bao N","Vinh PTK","Nghia ND","Lecaer JP"],"additional_accession":[]},"is_claimable":false,"name":"Isolation and structural identification of a new T1-conotoxin with unique disulfide connectivities derived from <i>Conus bandanus</i>.","description":"<h4>Background</h4>Conopeptides are neuropharmacological peptides derived from the venomous salivary glands of cone snails. Among 29 superfamilies based on conserved signal sequences, T-superfamily conotoxins, which belong to the smallest group, include four different frameworks that contain four cysteines denominated I, V, X and XVI. In this work, the primary structure and the cysteine connectivity of novel conotoxin of <i>Conus bandanus</i> were determined by tandem mass spectrometry using collision-induced dissociation.<h4>Methods</h4>The venom glands of <i>C. bandanus</i> snails were dissected, pooled, and extracted with 0.1% trifluoroacetic acid in three steps and lyophilized. The venom was fractionated and purified in an HPLC system with an analytical reversed-phase C<sub>18</sub> co","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-27T00:22:57.881Z","creation":"2020-05-23T07:05:34Z"},"accession":"S-EPMC7216822","cross_references":{"pubmed":["32425993"],"doi":["10.1590/1678-9199-JVATITD-2019-0095"]}}