{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dow L"],"funding":["Universität Konstanz","European Research Council","Deutsche Forschungsgemeinschaft","Fonds Wetenschappelijk Onderzoek","H2020 Marie Skłodowska-Curie Actions"],"pagination":["1206-1216"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7217009"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(8)"],"pubmed_abstract":["The mechanisms underlying interactions between diatoms and bacteria are crucial to understand diatom behaviour and proliferation, and can result in far-reaching ecological consequences. Recently, 2-alkyl-4-quinolones have been isolated from marine bacteria, both of which (the bacterium and isolated chemical) inhibited growth of microalgae, suggesting these compounds could mediate diatom-bacteria interactions. The effects of several quinolones on three diatom species have been investigated. The growth of all three was inhibited, with half-maximal inhibitory concentrations reaching the sub-micromolar range. By using multiple techniques, dual inhibition mechanisms were uncovered for 2-heptyl-4-quinolone (HHQ) in Phaeodactylum tricornutum. Firstly, photosynthetic electron transport was obstructed, primarily through inhibition of the cytochrome b<sub>6</sub> f complex. Secondly, respiration was inhibited, leading to repression of ATP supply to plastids from mitochondria through organelle energy coupling. These data clearly show how HHQ could modulate diatom proliferation in marine environments."],"journal":["Chembiochem : a European journal of chemical biology"],"pubmed_title":["The Multifaceted Inhibitory Effects of an Alkylquinolone on the Diatom Phaeodactylum tricornutum."],"pmcid":["PMC7217009"],"funding_grant_id":["KoRS-CB","250187465","EMBRC-ERIC","642575","LE 3358/3-1","715579"],"pubmed_authors":["Kroth PG","Prothiwa M","Szamosvari D","Dow L","Vyverman W","Bottcher T","Lepetit B","Peltekis A","Stock F","Lapointe A","Bailleul B"],"additional_accession":[]},"is_claimable":false,"name":"The Multifaceted Inhibitory Effects of an Alkylquinolone on the Diatom Phaeodactylum tricornutum.","description":"The mechanisms underlying interactions between diatoms and bacteria are crucial to understand diatom behaviour and proliferation, and can result in far-reaching ecological consequences. Recently, 2-alkyl-4-quinolones have been isolated from marine bacteria, both of which (the bacterium and isolated chemical) inhibited growth of microalgae, suggesting these compounds could mediate diatom-bacteria interactions. The effects of several quinolones on three diatom species have been investigated. The growth of all three was inhibited, with half-maximal inhibitory concentrations reaching the sub-micromolar range. By using multiple techniques, dual inhibition mechanisms were uncovered for 2-heptyl-4-quinolone (HHQ) in Phaeodactylum tricornutum. Firstly, photosynthetic electron transport was obstructed, primarily through inhibition of the cytochrome b<sub>6</sub> f complex. Secondly, respiration was inhibited, leading to repression of ATP supply to plastids from mitochondria through organelle energy coupling. These data clearly show how HHQ could modulate diatom proliferation in marine environments.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2025-04-27T00:21:54.583Z","creation":"2020-05-22T20:01:35Z"},"accession":"S-EPMC7217009","cross_references":{"pubmed":["31747114"],"doi":["10.1002/cbic.201900612"]}}