biostudies-literatureUmuhire Juru ANational Institute of Allergy and Infectious DiseasesDivision of ChemistryDuke UniversityNIAID NIH HHSProstate Cancer Foundation3555-3558https://www.ebi.ac.uk/biostudies/studies/S-EPMC7218690biostudies-literatureUnknown56(24)This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.Chemical communications (Cambridge, England)Template-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.PMC7218690Young Investigator AwardU54 AI150470CAREER 1750375Umuhire Juru ACai ZJan AHargrove AEfalseTemplate-guided selection of RNA ligands using imine-based dynamic combinatorial chemistry.This study establishes the applicability of imine-based dynamic combinatorial chemistry to discover non-covalent ligands for RNA targets. We elucidate properties underlying the reactivity of arylamines and demonstrate target-guided amplification of tight binders in an amiloride-based dynamic library.2020-01-01T00:00:00Z2020 Mar2025-04-04T23:51:23.969Z2025-04-04T23:51:23.969ZS-EPMC72186903210483910.1039/d0cc00266f