{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu F"],"funding":["Shanghai Pu-jiang Program","Shanghai Health Bureau","the National Natural Science Foundation of China"],"pagination":["1746573"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7219269"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Despite the success of monotherapies based on blockade of programmed cell death 1 (PD-1) in human melanoma, most patients do not experience durable clinical benefit. T-cell infiltration and/or the presence of PD-L1 in tumors may be used as indicators of clinical response; However, recent studies reported that preexisting tumor-specific T cells may have limited reinvigoration capacity. Therefore, evaluating status of T cells of tumor-adjacent area and its impact on the prognosis are very important. Here, we examined 117 surgical samples from HCC patients for infiltration of exhausted T cell (Tex) including CD4<sup>+</sup>-Tex, CD8<sup>+</sup>-Tex and regulatory T cell (FOXP3<sup>+</sup>-Treg) in tumor and adjacent tissue. CD3<sup>+</sup>CD45RO<sup>+</sup>T cells were sorted from adjacent ar"],"journal":["Oncoimmunology"],"pubmed_title":["Heterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinoma."],"pmcid":["PMC7219269"],"funding_grant_id":["81771672","17PJD006","201740101"],"pubmed_authors":["Sanin DE","Tian M","Lu Y","Qiao T","Jia G","Wang H","Wang X","Wu D","Zhu B","Liu F","Liu W","Shi Y"],"additional_accession":[]},"is_claimable":false,"name":"Heterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinoma.","description":"Despite the success of monotherapies based on blockade of programmed cell death 1 (PD-1) in human melanoma, most patients do not experience durable clinical benefit. T-cell infiltration and/or the presence of PD-L1 in tumors may be used as indicators of clinical response; However, recent studies reported that preexisting tumor-specific T cells may have limited reinvigoration capacity. Therefore, evaluating status of T cells of tumor-adjacent area and its impact on the prognosis are very important. Here, we examined 117 surgical samples from HCC patients for infiltration of exhausted T cell (Tex) including CD4<sup>+</sup>-Tex, CD8<sup>+</sup>-Tex and regulatory T cell (FOXP3<sup>+</sup>-Treg) in tumor and adjacent tissue. CD3<sup>+</sup>CD45RO<sup>+</sup>T cells were sorted from adjacent ar","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-04T19:05:27.113Z","creation":"2020-05-23T07:06:23Z"},"accession":"S-EPMC7219269","cross_references":{"pubmed":["32426177"],"doi":["10.1080/2162402X.2020.1746573"]}}