{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lichman BR"],"funding":["National Institute of Food and Agriculture","UK Research and Innovation","National Science Foundation"],"pagination":["eaba0721"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7220310"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(20)"],"pubmed_abstract":["Catnip or catmint (<i>Nepeta</i> spp.) is a flowering plant in the mint family (Lamiaceae) famed for its ability to attract cats. This phenomenon is caused by the compound nepetalactone, a volatile iridoid that also repels insects. Iridoids are present in many Lamiaceae species but were lost in the ancestor of the Nepetoideae, the subfamily containing <i>Nepeta</i>. Using comparative genomics, ancestral sequence reconstructions, and phylogenetic analyses, we probed the re-emergence of iridoid biosynthesis in <i>Nepeta</i>. The results of these investigations revealed mechanisms for the loss and subsequent re-evolution of iridoid biosynthesis in the <i>Nepeta</i> lineage. We present evidence for a chronology of events that led to the formation of nepetalactone biosynthesis and its metabolic"],"journal":["Science advances"],"pubmed_title":["The evolutionary origins of the cat attractant nepetalactone in catnip."],"pmcid":["PMC7220310"],"funding_grant_id":["MICL02431","MR/S01862X/1","IOS-1444499"],"pubmed_authors":["Kamileen MO","Vaillancourt B","O'Connor SE","Hamilton JP","Godden GT","Kinser TJ","Sun M","Soltis DE","Dudareva N","Soltis PS","Henry LK","Zhao D","Lichman BR","Palmer L","Wood JC","Rodriguez-Lopez C","Buell CR"],"additional_accession":[]},"is_claimable":false,"name":"The evolutionary origins of the cat attractant nepetalactone in catnip.","description":"Catnip or catmint (<i>Nepeta</i> spp.) is a flowering plant in the mint family (Lamiaceae) famed for its ability to attract cats. This phenomenon is caused by the compound nepetalactone, a volatile iridoid that also repels insects. Iridoids are present in many Lamiaceae species but were lost in the ancestor of the Nepetoideae, the subfamily containing <i>Nepeta</i>. Using comparative genomics, ancestral sequence reconstructions, and phylogenetic analyses, we probed the re-emergence of iridoid biosynthesis in <i>Nepeta</i>. The results of these investigations revealed mechanisms for the loss and subsequent re-evolution of iridoid biosynthesis in the <i>Nepeta</i> lineage. We present evidence for a chronology of events that led to the formation of nepetalactone biosynthesis and its metabolic","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2025-04-04T19:04:46.029Z","creation":"2020-05-23T07:06:34Z"},"accession":"S-EPMC7220310","cross_references":{"pubmed":["32426505"],"doi":["10.1126/sciadv.aba0721"]}}