biostudies-literatureHospach IBaxter14https://www.ebi.ac.uk/biostudies/studies/S-EPMC7221037biostudies-literatureUnknown8(1)BACKGROUND:Invasive mechanical ventilation is lifesaving in the setting of severe acute respiratory failure but can cause ventilation-induced lung injury. Advances in extracorporeal CO2 removal (ECCO2R) technologies may facilitate more protective lung ventilation in acute respiratory distress syndrome, and enable earlier weaning and/or avoid invasive mechanical ventilation entirely in chronic obstructive pulmonary disease exacerbations. We evaluated the in vitro CO2 removal capacity of the novel PrismaLung+ ECCO2R device compared with two existing gas exchangers. METHODS:The in vitro CO2 removal capacity of the PrismaLung+ (surface area 0.8 m2, Baxter) was compared with the PrismaLung (surface area 0.35 m2, Baxter) and A.L.ONE (surface area 1.35 m2, Eurosets) devices, using a closed-loop bIntensive care medicine experimentalIn vitro characterization of PrismaLung+: a novel ECCO2R device.PMC7221037N/AStorr MHarenski KLaffey JGHospach IPouchoulin DGoldstein JVotteler SRaible MfalseIn vitro characterization of PrismaLung+: a novel ECCO2R device.BACKGROUND:Invasive mechanical ventilation is lifesaving in the setting of severe acute respiratory failure but can cause ventilation-induced lung injury. Advances in extracorporeal CO2 removal (ECCO2R) technologies may facilitate more protective lung ventilation in acute respiratory distress syndrome, and enable earlier weaning and/or avoid invasive mechanical ventilation entirely in chronic obstructive pulmonary disease exacerbations. We evaluated the in vitro CO2 removal capacity of the novel PrismaLung+ ECCO2R device compared with two existing gas exchangers. METHODS:The in vitro CO2 removal capacity of the PrismaLung+ (surface area 0.8 m2, Baxter) was compared with the PrismaLung (surface area 0.35 m2, Baxter) and A.L.ONE (surface area 1.35 m2, Eurosets) devices, using a closed-loop b2020-01-01T00:00:00Z2020 May2025-06-01T03:23:01.083Z2020-05-22T20:13:29ZS-EPMC72210373240571410.1186/s40635-020-00301-7