{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(10)"],"submitter":["Zhou P"],"pubmed_abstract":["There were no ideal markers to predict the development of radiation pneumonitis (RP). We want to investigate the value of variations of lymphocytes and T lymphocyte subsets in predicting RP after radiotherapy (RT) of lung cancer based on previous clinical findings. A total of 182 lung cancer patients who received RT were retrospectively analyzed. Circulating lymphocytes and T lymphocyte subsets were measured before, during, and after RT. Patients were evaluated from the start of RT to 6 months post-RT. A mice model with acute radiation-induced lung injury was established and circulating lymphocytes were measured weekly until 8 weeks after irradiation. Univariate and multivariate analyses were adopted to identify risk factors of RP. Lymphocyte levels significantly decreased (P < .001) in pa"],"journal":["Cancer medicine"],"pagination":["3437-3444"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7221303"],"repository":["biostudies-literature"],"pubmed_title":["Early variations in lymphocytes and T lymphocyte subsets are associated with radiation pneumonitis in lung cancer patients and experimental mice received thoracic irradiation."],"pmcid":["PMC7221303"],"pubmed_authors":["Li G","Huang C","Chun C","Zhou P","Chen L","Chen G","Luo W","Yan D","Zhang S","Wang Z","Zhong L","Chen D"],"additional_accession":[]},"is_claimable":false,"name":"Early variations in lymphocytes and T lymphocyte subsets are associated with radiation pneumonitis in lung cancer patients and experimental mice received thoracic irradiation.","description":"There were no ideal markers to predict the development of radiation pneumonitis (RP). We want to investigate the value of variations of lymphocytes and T lymphocyte subsets in predicting RP after radiotherapy (RT) of lung cancer based on previous clinical findings. A total of 182 lung cancer patients who received RT were retrospectively analyzed. Circulating lymphocytes and T lymphocyte subsets were measured before, during, and after RT. Patients were evaluated from the start of RT to 6 months post-RT. A mice model with acute radiation-induced lung injury was established and circulating lymphocytes were measured weekly until 8 weeks after irradiation. Univariate and multivariate analyses were adopted to identify risk factors of RP. Lymphocyte levels significantly decreased (P < .001) in pa","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2025-05-29T21:16:25.93Z","creation":"2025-05-29T21:16:25.93Z"},"accession":"S-EPMC7221303","cross_references":{"pubmed":["32207253"],"doi":["10.1002/cam4.2987"]}}