{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang L"],"funding":["NHLBI NIH HHS","NINDS NIH HHS","National Institutes of Health"],"pagination":["2030-2041"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7225048"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["432(7)"],"pubmed_abstract":["<h4>Aims</h4>Several signaling pathways contribute to endothelial-mesenchymal transitions and vascular calcification, including bone morphogenetic protein (BMP) and transforming growth factor (TGF) β signaling. The transcription factor homeobox D3 (Hoxd3) is known to regulate an invasive endothelial phenotype, and the aim of the study is to determine if HOXD3 modulates BMP and TGFβ signaling in the endothelium.<h4>Methods and research</h4>We report that the endothelium with high BMP activity due to the loss of BMP inhibitor matrix Gla protein (MGP) shows induction of Hoxd3. HOXD3 is part of a BMP-triggered cascade. When activated by BMP9, activin receptor-like kinase (ALK) 1 induces HOXD3 expression. Hoxd3 promoter is a direct target of phosphorylated (p) SMAD1, a mediator of BMP signaling"],"journal":["Journal of molecular biology"],"pubmed_title":["Homeobox D3, A Novel Link Between Bone Morphogenetic Protein 9 and Transforming Growth Factor Beta 1 Signaling."],"pmcid":["PMC7225048"],"funding_grant_id":["P01 HL030568","HL30568","NS79353","R01 NS079353","R01 HL081397","HL139675","R01 HL139675","HL81397"],"pubmed_authors":["Bostrom KI","Yao J","Yao Z","Zhang D","Qiao X","Yao Y","Yu T","Zhang L","Wang L","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Homeobox D3, A Novel Link Between Bone Morphogenetic Protein 9 and Transforming Growth Factor Beta 1 Signaling.","description":"<h4>Aims</h4>Several signaling pathways contribute to endothelial-mesenchymal transitions and vascular calcification, including bone morphogenetic protein (BMP) and transforming growth factor (TGF) β signaling. The transcription factor homeobox D3 (Hoxd3) is known to regulate an invasive endothelial phenotype, and the aim of the study is to determine if HOXD3 modulates BMP and TGFβ signaling in the endothelium.<h4>Methods and research</h4>We report that the endothelium with high BMP activity due to the loss of BMP inhibitor matrix Gla protein (MGP) shows induction of Hoxd3. HOXD3 is part of a BMP-triggered cascade. When activated by BMP9, activin receptor-like kinase (ALK) 1 induces HOXD3 expression. Hoxd3 promoter is a direct target of phosphorylated (p) SMAD1, a mediator of BMP signaling","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Mar","modification":"2025-04-04T23:49:48.492Z","creation":"2025-04-04T23:49:48.492Z"},"accession":"S-EPMC7225048","cross_references":{"pubmed":["32061928"],"doi":["10.1016/j.jmb.2020.01.043"]}}