{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hadzijusufovic E"],"funding":["Oesterreichische Nationalbank","Austrian Science Fund FWF"],"pagination":["E1021"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7225958"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(4)"],"pubmed_abstract":["Janus kinase 2 (JAK2) and signal transducer and activator of transcription-5 (STAT5) play a key role in the pathogenesis of myeloproliferative neoplasms (MPN). In most patients, <i>JAK2</i> V617F or <i>CALR</i> mutations are found and lead to activation of various downstream signaling cascades and molecules, including STAT5. We examined the presence and distribution of phosphorylated (p) STAT5 in neoplastic cells in patients with MPN, including polycythemia vera (PV, <i>n</i> = 10), essential thrombocythemia (ET, <i>n</i> = 15) and primary myelofibrosis (PMF, <i>n</i> = 9), and in the <i>JAK2</i> V617F-positive cell lines HEL and SET-2. As assessed by immunohistochemistry, MPN cells displayed pSTAT5 in all patients examined. Phosphorylated STAT5 was also detected in putative CD34<sup>+</su"],"journal":["Cancers"],"pubmed_title":["STAT5 is Expressed in CD34<sup>+</sup>/CD38<sup>-</sup> Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms."],"pmcid":["PMC7225958"],"funding_grant_id":["I 4157","F4701‐B20, F4702‐B20, F4704‐B20, F4707‐B20, F6105‐B20","14835"],"pubmed_authors":["Filik Y","Moriggl R","Witzeneder N","Nivarthi H","Park J","Gouilleux F","de Araujo ED","Gunning PT","Berger D","Wingelhofer B","Mullauer L","Tin G","Keller A","Greiner G","Schur FKM","Hoermann G","Kralovics R","Valent P","Ivanov D","Pecnard E","Kornauth C","Neubauer HA","Hadzijusufovic E"],"additional_accession":[]},"is_claimable":false,"name":"STAT5 is Expressed in CD34<sup>+</sup>/CD38<sup>-</sup> Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms.","description":"Janus kinase 2 (JAK2) and signal transducer and activator of transcription-5 (STAT5) play a key role in the pathogenesis of myeloproliferative neoplasms (MPN). In most patients, <i>JAK2</i> V617F or <i>CALR</i> mutations are found and lead to activation of various downstream signaling cascades and molecules, including STAT5. We examined the presence and distribution of phosphorylated (p) STAT5 in neoplastic cells in patients with MPN, including polycythemia vera (PV, <i>n</i> = 10), essential thrombocythemia (ET, <i>n</i> = 15) and primary myelofibrosis (PMF, <i>n</i> = 9), and in the <i>JAK2</i> V617F-positive cell lines HEL and SET-2. As assessed by immunohistochemistry, MPN cells displayed pSTAT5 in all patients examined. Phosphorylated STAT5 was also detected in putative CD34<sup>+</su","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2025-06-01T03:23:32.715Z","creation":"2020-05-23T07:07:46Z"},"accession":"S-EPMC7225958","cross_references":{"pubmed":["32326377"],"doi":["10.3390/cancers12041021"]}}