{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chao CM"],"funding":["Deutsche Forschungsgemeinschaft, DZL, First Affiliated Hospital of Wenzhou Medical University"],"pagination":["E859"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7226730"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(4)"],"pubmed_abstract":["<h4>Background</h4>Bronchopulmonary dysplasia (BPD) is a lung disease of preterm born infants, characterized by alveolar simplification. MicroRNA (<i>miR)</i> are known to be involved in many biological and pathological processes in the lung. Although a changed expression has been described for several <i>miR</i> in BPD, a causal role remains to be established.<h4>Results</h4>Our results showed that the expression level of <i>miR-154</i> increases during lung development and decreases postnatally. Further, hyperoxia treatment maintains high levels of <i>miR-154</i> in alveolar type 2 cells (AT2). We hypothesized that the decrease in <i>miR-154</i> expression in AT2 cells is required for normal alveologenesis. To test this hypothesis, we generated a novel transgenic mouse allowing doxycycli"],"journal":["Cells"],"pubmed_title":["Failure to Down-Regulate <i>miR-154</i> Expression in Early Postnatal Mouse Lung Epithelium Suppresses Alveologenesis, with Changes in Tgf-β Signaling Similar to those Induced by Exposure to Hyperoxia."],"pmcid":["PMC7226730"],"funding_grant_id":["DFG; BE4443/14-1, BE4443/6-1, KFO309 P7 and SFB CRC1213-projects A02 and A04","Clinical career grant"],"pubmed_authors":["Wu J","Barreto G","Bellusci S","Sedighi J","Chong L","Kolck J","Minoo P","Moiseenko A","Rako ZA","Carraro G","Warburton D","Young BM","Chao CM","Contreras A","Zimmermann V","Wilhelm J"],"additional_accession":[]},"is_claimable":false,"name":"Failure to Down-Regulate <i>miR-154</i> Expression in Early Postnatal Mouse Lung Epithelium Suppresses Alveologenesis, with Changes in Tgf-β Signaling Similar to those Induced by Exposure to Hyperoxia.","description":"<h4>Background</h4>Bronchopulmonary dysplasia (BPD) is a lung disease of preterm born infants, characterized by alveolar simplification. MicroRNA (<i>miR)</i> are known to be involved in many biological and pathological processes in the lung. Although a changed expression has been described for several <i>miR</i> in BPD, a causal role remains to be established.<h4>Results</h4>Our results showed that the expression level of <i>miR-154</i> increases during lung development and decreases postnatally. Further, hyperoxia treatment maintains high levels of <i>miR-154</i> in alveolar type 2 cells (AT2). We hypothesized that the decrease in <i>miR-154</i> expression in AT2 cells is required for normal alveologenesis. To test this hypothesis, we generated a novel transgenic mouse allowing doxycycli","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2026-04-17T15:24:07.67Z","creation":"2020-05-23T07:09:43Z"},"accession":"S-EPMC7226730","cross_references":{"pubmed":["32252341"],"doi":["10.3390/cells9040859"]}}