{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu N"],"funding":["Ministry of Science and Technology of the People's Republic of China","National Natural Science Foundation of China"],"pagination":["10415-10422"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7226858"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(18)"],"pubmed_abstract":["The application of disulfiram can be traced back to the 1920s, from when it was utilized to facilitate alcohol abstinence by producing allergic reactions toward alcohol. In previous research, combination of disulfiram and copper ions has demonstrated significant anti-tumor activity. However, both disulfiram and copper ions lack the ability of specific targeting to tumor tissues and may lead to a high risk of side effects, especially for copper ion, which is a kind of toxic heavy metal. Herein, a ferritin-albumin-Cu nanoparticle (FHC NP) was introduced. The nanoparticle was synthesized by first covalently cross-linking ferritin and albumin and then encapsulating the copper ions in the ferritin nanocage. The nanoparticle showed good accumulation in a tumor and when combined with disulfiram e"],"journal":["ACS omega"],"pubmed_title":["A Ferritin-Albumin-Cu Nanoparticle that Efficaciously Delivers Copper(II) Ions to a Tumor and Improves the Therapeutic Efficacy of Disulfiram."],"pmcid":["PMC7226858"],"funding_grant_id":["31471299","2018ZX09711003","81522046"],"pubmed_authors":["Xu N","Yang YF","Chen L","Lin J"],"additional_accession":[]},"is_claimable":false,"name":"A Ferritin-Albumin-Cu Nanoparticle that Efficaciously Delivers Copper(II) Ions to a Tumor and Improves the Therapeutic Efficacy of Disulfiram.","description":"The application of disulfiram can be traced back to the 1920s, from when it was utilized to facilitate alcohol abstinence by producing allergic reactions toward alcohol. In previous research, combination of disulfiram and copper ions has demonstrated significant anti-tumor activity. However, both disulfiram and copper ions lack the ability of specific targeting to tumor tissues and may lead to a high risk of side effects, especially for copper ion, which is a kind of toxic heavy metal. Herein, a ferritin-albumin-Cu nanoparticle (FHC NP) was introduced. The nanoparticle was synthesized by first covalently cross-linking ferritin and albumin and then encapsulating the copper ions in the ferritin nanocage. The nanoparticle showed good accumulation in a tumor and when combined with disulfiram e","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2026-04-30T03:29:11.031Z","creation":"2020-05-23T07:11:55Z"},"accession":"S-EPMC7226858","cross_references":{"pubmed":["32426598"],"doi":["10.1021/acsomega.0c00293"]}}