{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lubyayi L"],"funding":["Medical Research Council","Wellcome Trust"],"pagination":["929"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7240028"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["<b>Background:</b> BCG has low efficacy in tropical countries. We hypothesized that maternal latent <i>Mycobacterium tuberculosis (M.tb)</i> infection (LTBI) results in fetal tolerance to mycobacterial antigens and impaired responses to BCG immunization. <b>Methods:</b> We enrolled 132 LTBI-positive and 150 LTBI-negative mothers and their babies in Entebbe, Uganda. Infants were BCG-immunized at birth. Cord blood and samples at weeks 1, 4, 6, 10, 14, 24, and 52 were analyzed for cytokine/chemokine responses to <i>M.tb</i> antigens by Luminex 17-plex assay in 6-day whole blood cultures and antibody responses by ELISA. Of the 17 Luminex analytes, seven (IL-2, IL-5, IL-10, IL-13, IL-17A, TNF, and IFN-γ) were included in the main analysis as they were considered most likely to represent T cell "],"journal":["Frontiers in immunology"],"pubmed_title":["Maternal Latent <i>Mycobacterium tuberculosis</i> Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda."],"pmcid":["PMC7240028"],"funding_grant_id":["MC_UU_00027/5","MC_PC_17221","MR/K012126/1","MC_UP_1204/15","MR/K019708/1","MR/R005990/1","107754/Z/15/Z","MR/R005990/2"],"pubmed_authors":["Akurut H","Nabakooza G","Hasso-Agopsowicz M","Mawa PA","Kaleebu P","Levin J","Serubanja J","Tumusiime J","Dockrell HM","Webb EL","Nakibuule M","Smith S","Tushabe JV","Cose S","Elliott AM","Aibo D","Lubyayi L"],"additional_accession":[]},"is_claimable":false,"name":"Maternal Latent <i>Mycobacterium tuberculosis</i> Does Not Affect the Infant Immune Response Following BCG at Birth: An Observational Longitudinal Study in Uganda.","description":"<b>Background:</b> BCG has low efficacy in tropical countries. We hypothesized that maternal latent <i>Mycobacterium tuberculosis (M.tb)</i> infection (LTBI) results in fetal tolerance to mycobacterial antigens and impaired responses to BCG immunization. <b>Methods:</b> We enrolled 132 LTBI-positive and 150 LTBI-negative mothers and their babies in Entebbe, Uganda. Infants were BCG-immunized at birth. Cord blood and samples at weeks 1, 4, 6, 10, 14, 24, and 52 were analyzed for cytokine/chemokine responses to <i>M.tb</i> antigens by Luminex 17-plex assay in 6-day whole blood cultures and antibody responses by ELISA. Of the 17 Luminex analytes, seven (IL-2, IL-5, IL-10, IL-13, IL-17A, TNF, and IFN-γ) were included in the main analysis as they were considered most likely to represent T cell ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-18T13:25:35.251Z","creation":"2020-06-02T07:08:18Z"},"accession":"S-EPMC7240028","cross_references":{"pubmed":["32477371"],"doi":["10.3389/fimmu.2020.00929"]}}