{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Finch CL"],"funding":["CCR NIH HHS","NIAID NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing an exponentially increasing number of coronavirus disease 19 (COVID-19) cases globally. Prioritization of medical countermeasures for evaluation in randomized clinical trials is critically hindered by the lack of COVID-19 animal models that enable accurate, quantifiable, and reproducible measurement of COVID-19 pulmonary disease free from observer bias. We first used serial computed tomography (CT) to demonstrate that bilateral intrabronchial instillation of SARS-CoV-2 into crab-eating macaques (<i>Macaca fascicularis</i>) results in mild-to-moderate lung abnormalities qualitatively characteristic of subclinical or mild-to-moderate COVID-19 (e.g., ground-glass opacities with or without reticulation, paving, or alveolar"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2020.05.14.096727"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7241101"],"repository":["biostudies-literature"],"pubmed_title":["Characteristic and quantifiable COVID-19-like abnormalities in CT- and PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques (&lt;i&gt;Macaca fascicularis&lt;/i&gt;)."],"pmcid":["PMC7241101"],"funding_grant_id":["T32 GM008692","F30 AI145182","HHSN261200800001E","HHSN261200800001C","HHSN272201800013C"],"pubmed_authors":["Bartos C","Friedrich TC","Braun KM","Solomon J","Kuhn JH","Castro M","Larson PA","Kugelman JR","Feuerstein IM","Aiosa NM","Nason MC","Liang J","Kocher G","O'Connor DH","St Claire MC","Lee JH","Finch CL","Burdette T","Di Paola N","Ramuta MD","Wada J","Crozier I","Kurtz JR","Sayre PJ","Adams R","Schmaljohn CS","Byrum R","Beitzel B","Johnson RF","Lackemeyer MG","Sharer K","Cooper TK","Palacios G"],"additional_accession":[]},"is_claimable":false,"name":"Characteristic and quantifiable COVID-19-like abnormalities in CT- and PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques (&lt;i&gt;Macaca fascicularis&lt;/i&gt;).","description":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing an exponentially increasing number of coronavirus disease 19 (COVID-19) cases globally. Prioritization of medical countermeasures for evaluation in randomized clinical trials is critically hindered by the lack of COVID-19 animal models that enable accurate, quantifiable, and reproducible measurement of COVID-19 pulmonary disease free from observer bias. We first used serial computed tomography (CT) to demonstrate that bilateral intrabronchial instillation of SARS-CoV-2 into crab-eating macaques (<i>Macaca fascicularis</i>) results in mild-to-moderate lung abnormalities qualitatively characteristic of subclinical or mild-to-moderate COVID-19 (e.g., ground-glass opacities with or without reticulation, paving, or alveolar","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2026-05-19T03:11:44.23Z","creation":"2024-11-12T15:43:50.853Z"},"accession":"S-EPMC7241101","cross_references":{"pubmed":["32511338"],"doi":["10.1101/2020.05.14.096727"]}}