biostudies-literatureUnknownFinch CLCCR NIH HHSNIAID NIH HHSNCI NIH HHSNIGMS NIH HHSSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing an exponentially increasing number of coronavirus disease 19 (COVID-19) cases globally. Prioritization of medical countermeasures for evaluation in randomized clinical trials is critically hindered by the lack of COVID-19 animal models that enable accurate, quantifiable, and reproducible measurement of COVID-19 pulmonary disease free from observer bias. We first used serial computed tomography (CT) to demonstrate that bilateral intrabronchial instillation of SARS-CoV-2 into crab-eating macaques (<i>Macaca fascicularis</i>) results in mild-to-moderate lung abnormalities qualitatively characteristic of subclinical or mild-to-moderate COVID-19 (e.g., ground-glass opacities with or without reticulation, paving, or alveolarbioRxiv : the preprint server for biology2020.05.14.096727https://www.ebi.ac.uk/biostudies/studies/S-EPMC7241101biostudies-literatureCharacteristic and quantifiable COVID-19-like abnormalities in CT- and PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques (&lt;i&gt;Macaca fascicularis&lt;/i&gt;).PMC7241101T32 GM008692F30 AI145182HHSN261200800001EHHSN261200800001CHHSN272201800013CBartos CFriedrich TCBraun KMSolomon JKuhn JHCastro MLarson PAKugelman JRFeuerstein IMAiosa NMNason MCLiang JKocher GO'Connor DHSt Claire MCLee JHFinch CLBurdette TDi Paola NRamuta MDWada JCrozier IKurtz JRSayre PJAdams RSchmaljohn CSByrum RBeitzel BJohnson RFLackemeyer MGSharer KCooper TKPalacios GfalseCharacteristic and quantifiable COVID-19-like abnormalities in CT- and PET/CT-imaged lungs of SARS-CoV-2-infected crab-eating macaques (&lt;i&gt;Macaca fascicularis&lt;/i&gt;).Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing an exponentially increasing number of coronavirus disease 19 (COVID-19) cases globally. Prioritization of medical countermeasures for evaluation in randomized clinical trials is critically hindered by the lack of COVID-19 animal models that enable accurate, quantifiable, and reproducible measurement of COVID-19 pulmonary disease free from observer bias. We first used serial computed tomography (CT) to demonstrate that bilateral intrabronchial instillation of SARS-CoV-2 into crab-eating macaques (<i>Macaca fascicularis</i>) results in mild-to-moderate lung abnormalities qualitatively characteristic of subclinical or mild-to-moderate COVID-19 (e.g., ground-glass opacities with or without reticulation, paving, or alveolar2020-01-01T00:00:00Z2020 May2026-05-19T03:11:44.23Z2024-11-12T15:43:50.853ZS-EPMC72411013251133810.1101/2020.05.14.096727