biostudies-literatureUnknown12(9)Perez-Martinez L<h4>Background</h4>As age increases, the risk of developing fragility also increases. Improving the knowledge of frailty could contribute to maintaining the functional ability of elderly people. Interleukin (IL)-10 homozygous knockout mice (IL-10^tm/tm [IL10KO]) constitute an excellent tool for the study of frailty. Because patients with frailty demonstrate an overexpression of CCR5, rapamycin (RAPA) and/or maraviroc (MVC), two molecules able to decrease CCR5 expression, were evaluated.<h4>Results</h4>Muscle myostatin was reduced in all the therapeutic groups but the MVC group (p <0.001 for RAPA and MVC-RAPA) and in serum samples (p <0.01 for all the groups). Serum CK levels were also significantly lower in MVC and RAPA groups (p <0.01 in both cases). Lower AST levels were observAging8565-8582https://www.ebi.ac.uk/biostudies/studies/S-EPMC7244075biostudies-literatureImplications of maraviroc and/or rapamycin in a mouse model of fragility.PMC7244075Carnero AMunoz-Galvan SPerez-Martinez LRomero LRubio-Mediavilla SOteo JAVerdugo-Sivianes EMBlanco JRfalseImplications of maraviroc and/or rapamycin in a mouse model of fragility.<h4>Background</h4>As age increases, the risk of developing fragility also increases. Improving the knowledge of frailty could contribute to maintaining the functional ability of elderly people. Interleukin (IL)-10 homozygous knockout mice (IL-10^tm/tm [IL10KO]) constitute an excellent tool for the study of frailty. Because patients with frailty demonstrate an overexpression of CCR5, rapamycin (RAPA) and/or maraviroc (MVC), two molecules able to decrease CCR5 expression, were evaluated.<h4>Results</h4>Muscle myostatin was reduced in all the therapeutic groups but the MVC group (p <0.001 for RAPA and MVC-RAPA) and in serum samples (p <0.01 for all the groups). Serum CK levels were also significantly lower in MVC and RAPA groups (p <0.01 in both cases). Lower AST levels were observ2020-01-01T00:00:00Z2020 Apr2025-04-18T14:36:01.65Z2020-06-07T07:12:14ZS-EPMC72440753235383010.18632/aging.103167