{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["27(6)"],"submitter":["Xu C"],"pubmed_abstract":["Human telomerase RNA component hTERC comprises multiple motifs that contribute to hTERC biogenesis, holoenzyme activity, and enzyme recruitment to telomeres. hTERC contains several guanine tracts (G-tracts) at its 5'-end, but its associated proteins and potential roles in telomerase function are still poorly understood. The heterogeneous nuclear ribonucleoproteins F, H1, and H2 (hnRNP F/H) are splicing factors that preferentially bind to poly(G)-rich sequences RNA. Here, we demonstrate that hnRNP F/H associate with both hTERC and telomerase holoenzyme to regulate telomerase activity. We reveal hnRNP F/H bind to the 5'-end region of hTERC in vitro and in vivo, and identify the first three G-tracts of hTERC and qRRM1 domain of hnRNP F/H are required for their interaction. Furthermore, hnRNP "],"journal":["Cell death and differentiation"],"pagination":["1998-2013"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7244589"],"repository":["biostudies-literature"],"pubmed_title":["HnRNP F/H associate with hTERC and telomerase holoenzyme to modulate telomerase function and promote cell proliferation."],"pmcid":["PMC7244589"],"pubmed_authors":["Li G","Han L","Chen J","Liang Y","Xing X","Xu C","Zhang N","Xie N","Sun Z","Tong T","Jia S","Su Y","Liu D"],"additional_accession":[]},"is_claimable":false,"name":"HnRNP F/H associate with hTERC and telomerase holoenzyme to modulate telomerase function and promote cell proliferation.","description":"Human telomerase RNA component hTERC comprises multiple motifs that contribute to hTERC biogenesis, holoenzyme activity, and enzyme recruitment to telomeres. hTERC contains several guanine tracts (G-tracts) at its 5'-end, but its associated proteins and potential roles in telomerase function are still poorly understood. The heterogeneous nuclear ribonucleoproteins F, H1, and H2 (hnRNP F/H) are splicing factors that preferentially bind to poly(G)-rich sequences RNA. Here, we demonstrate that hnRNP F/H associate with both hTERC and telomerase holoenzyme to regulate telomerase activity. We reveal hnRNP F/H bind to the 5'-end region of hTERC in vitro and in vivo, and identify the first three G-tracts of hTERC and qRRM1 domain of hnRNP F/H are required for their interaction. Furthermore, hnRNP ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-04T23:40:02.419Z","creation":"2020-06-07T07:13:07Z"},"accession":"S-EPMC7244589","cross_references":{"pubmed":["31863069"],"doi":["10.1038/s41418-019-0483-6"]}}