{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Conefrey C"],"funding":["Medical Research Council","National Institute for Health Research (NIHR)","National Institute of Health Research Health Technology Assessment programme","National Institute for Health Research University College London Hospitals Biomedical Research Centre, United Kingdom"],"pagination":["382-389"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7246331"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(6)"],"pubmed_abstract":["Aims
De-escalation trials are challenging and sometimes may fail due to poor recruitment. The OPTIMA Prelim randomised controlled trial (ISRCTN42400492) randomised patients with early stage breast cancer to chemotherapy versus 'test-directed' chemotherapy, with a possible outcome of no chemotherapy, which could confer less treatment relative to routine practice. Despite encountering challenges, OPTIMA Prelim reached its recruitment target ahead of schedule. This study reports the root causes of recruitment challenges and the strategies used to successfully overcome them.Materials and methods
A mixed-methods recruitment intervention (QuinteT Recruitment Intervention) was used to investigate the recruitment difficulties and feedback findings to inform interventions and optimi"],"journal":["Clinical oncology (Royal College of Radiologists (Great Britain))"],"pubmed_title":["Strategies to Improve Recruitment to a De-escalation Trial: A Mixed-Methods Study of the OPTIMA Prelim Trial in Early Breast Cancer."],"pmcid":["PMC7246331"],"funding_grant_id":["10/34/01","NIHR200268","06/303/98","MR/K025643/1"],"pubmed_authors":["Stein RC","Rea D","Donovan JL","Bartlett J","Makris A","Paramasivan S","Rooshenas L","Poole C","Cameron D","Macpherson I","Morgan A","Hughes-Davies L","Hall P","Earl H","Marshall A","Dunn J","Campbell A","Conefrey C","Pinder S","OPTIMA Prelim Study Group","Harmer V"],"additional_accession":[]},"is_claimable":false,"name":"Strategies to Improve Recruitment to a De-escalation Trial: A Mixed-Methods Study of the OPTIMA Prelim Trial in Early Breast Cancer.","description":"Aims
De-escalation trials are challenging and sometimes may fail due to poor recruitment. The OPTIMA Prelim randomised controlled trial (ISRCTN42400492) randomised patients with early stage breast cancer to chemotherapy versus 'test-directed' chemotherapy, with a possible outcome of no chemotherapy, which could confer less treatment relative to routine practice. Despite encountering challenges, OPTIMA Prelim reached its recruitment target ahead of schedule. This study reports the root causes of recruitment challenges and the strategies used to successfully overcome them.Materials and methods
A mixed-methods recruitment intervention (QuinteT Recruitment Intervention) was used to investigate the recruitment difficulties and feedback findings to inform interventions and optimi","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2026-07-15T22:08:39.209Z","creation":"2026-07-09T10:20:30.689Z"},"accession":"S-EPMC7246331","cross_references":{"pubmed":["32089356"],"doi":["10.1016/j.clon.2020.01.029"]}}