{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ji J"],"funding":["National Natural Science Foundation of China"],"pagination":["242"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7247226"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>Cardiac fibroblasts, regarded as the immunomodulatory hub of the heart, have been thought to play an important role during sepsis-induced cardiomyopathy (SIC). However, the detailed molecular mechanism and targeted therapies for SIC are still lacking. Therefore, we sought to investigate the likely protective effects of rolipram, an anti-inflammatory drug, on lipopolysaccharide (LPS)-stimulated inflammatory responses in cardiac fibroblasts and on cardiac dysfunction in endotoxic mice.<h4>Method</h4>Cardiac fibroblasts were isolated and stimulated with 1 μg/ml LPS for 6 h, and 10 μmol/l rolipram was administered for 1 h before LPS stimulation. mRNA levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in fibroblasts and their protein co"],"journal":["BMC cardiovascular disorders"],"pubmed_title":["Protective effects of rolipram on endotoxic cardiac dysfunction via inhibition of the inflammatory response in cardiac fibroblasts."],"pmcid":["PMC7247226"],"funding_grant_id":["81571940; 81741125"],"pubmed_authors":["Liu Z","Liu J","Hong X","Gao J","Ji J"],"additional_accession":[]},"is_claimable":false,"name":"Protective effects of rolipram on endotoxic cardiac dysfunction via inhibition of the inflammatory response in cardiac fibroblasts.","description":"<h4>Background</h4>Cardiac fibroblasts, regarded as the immunomodulatory hub of the heart, have been thought to play an important role during sepsis-induced cardiomyopathy (SIC). However, the detailed molecular mechanism and targeted therapies for SIC are still lacking. Therefore, we sought to investigate the likely protective effects of rolipram, an anti-inflammatory drug, on lipopolysaccharide (LPS)-stimulated inflammatory responses in cardiac fibroblasts and on cardiac dysfunction in endotoxic mice.<h4>Method</h4>Cardiac fibroblasts were isolated and stimulated with 1 μg/ml LPS for 6 h, and 10 μmol/l rolipram was administered for 1 h before LPS stimulation. mRNA levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL-1β) in fibroblasts and their protein co","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2025-04-25T21:37:44.656Z","creation":"2020-06-05T07:04:53Z"},"accession":"S-EPMC7247226","cross_references":{"pubmed":["32448150"],"doi":["10.1186/s12872-020-01529-7"]}}