{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Weir K"],"funding":["Chicago Community Trust","New York Stem Cell Foundation","Swiss National Science Foundation","NIDDK NIH HHS","Alfred P. Sloan Foundation","NINDS NIH HHS","National Institutes of Health","NIH HHS","NIGMS NIH HHS","Esther A. and Joseph Klingenstein Fund"],"pagination":["e57578"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7250568"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["All animals detect and integrate diverse environmental signals to mediate behavior. Cnidarians, including jellyfish and sea anemones, both detect and capture prey using stinging cells called nematocytes which fire a venom-covered barb via an unknown triggering mechanism. Here, we show that nematocytes from <i>Nematostella vectensis</i> use a specialized voltage-gated calcium channel (nCa<sub>V</sub>) to distinguish salient sensory cues and control the explosive discharge response. Adaptations in nCa<sub>V</sub> confer unusually sensitive, voltage-dependent inactivation to inhibit responses to non-prey signals, such as mechanical water turbulence. Prey-derived chemosensory signals are synaptically transmitted to acutely relieve nCa<sub>V</sub> inactivation, enabling mechanosensitive-trigger"],"journal":["eLife"],"pubmed_title":["A molecular filter for the cnidarian stinging response."],"pmcid":["PMC7250568"],"funding_grant_id":["P400PB-180894","180894","P2SKP3-187684","Searle Scholars Program","R35 GM142697","P2SKP3_187684","187684","Robertson Neuroscience Investigator","Klingenstein-Simons Fellowship","F31 NS117055","R00DK115879","U24 NS109102","R00 DK115879","1F31NS117055"],"pubmed_authors":["Weir K","Bellono NW","van Giesen L","Dupre C","Lee AS"],"additional_accession":[]},"is_claimable":false,"name":"A molecular filter for the cnidarian stinging response.","description":"All animals detect and integrate diverse environmental signals to mediate behavior. Cnidarians, including jellyfish and sea anemones, both detect and capture prey using stinging cells called nematocytes which fire a venom-covered barb via an unknown triggering mechanism. Here, we show that nematocytes from <i>Nematostella vectensis</i> use a specialized voltage-gated calcium channel (nCa<sub>V</sub>) to distinguish salient sensory cues and control the explosive discharge response. Adaptations in nCa<sub>V</sub> confer unusually sensitive, voltage-dependent inactivation to inhibit responses to non-prey signals, such as mechanical water turbulence. Prey-derived chemosensory signals are synaptically transmitted to acutely relieve nCa<sub>V</sub> inactivation, enabling mechanosensitive-trigger","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2026-05-04T02:05:03.917Z","creation":"2020-06-01T07:06:00Z"},"accession":"S-EPMC7250568","cross_references":{"pubmed":["32452384"],"doi":["10.7554/eLife.57578"]}}