{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen H"],"funding":["State Administration of Traditional Chinese Medicine of the People&apos;s Republic of China"],"pagination":["1706837"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7256709"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2020"],"pubmed_abstract":["The inflammatory proliferation of fibroblast-like synoviocytes (FLSs) and functional imbalances in T lymphocytes play critical roles in the pathogenesis of rheumatoid arthritis (RA). The clinical efficacy of Huayu Tongbi Fang (HYTB, a traditional herbal formula) in RA treatment has been validated. In this study, we aimed to explore the regulatory mechanisms of HYTB on the proliferation and differentiation of T lymphocytes, and the inhibitory effect of HYTB on inflammatory proliferation of FLSs. The RCS-364 (Rat FLSs) cells were cocultured with rat splenic lymphocytes that were induced by interleukin-1<i>β</i> in Transwell chambers. After freeze-dried HYTB powder treatment, the percentage of T-cell subset and apoptosis rates of FLSs were measured using flow cytometry. Furthermore, protein e"],"journal":["Evidence-based complementary and alternative medicine : eCAM"],"pubmed_title":["Chinese Herbal Formula, Huayu Tongbi Fang, Attenuates Inflammatory Proliferation of Rat Synoviocytes Induced by IL-1<i>β</i> by Regulating Proliferation and Differentiation of T Lymphocytes."],"pmcid":["PMC7256709"],"funding_grant_id":["JDZX2015191","2019-JYB-XS-177"],"pubmed_authors":["Li X","Liu J","Chai L","Li J","Wang C","Zhang H","Huandike M","Chen H","Huang Q","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Chinese Herbal Formula, Huayu Tongbi Fang, Attenuates Inflammatory Proliferation of Rat Synoviocytes Induced by IL-1<i>β</i> by Regulating Proliferation and Differentiation of T Lymphocytes.","description":"The inflammatory proliferation of fibroblast-like synoviocytes (FLSs) and functional imbalances in T lymphocytes play critical roles in the pathogenesis of rheumatoid arthritis (RA). The clinical efficacy of Huayu Tongbi Fang (HYTB, a traditional herbal formula) in RA treatment has been validated. In this study, we aimed to explore the regulatory mechanisms of HYTB on the proliferation and differentiation of T lymphocytes, and the inhibitory effect of HYTB on inflammatory proliferation of FLSs. The RCS-364 (Rat FLSs) cells were cocultured with rat splenic lymphocytes that were induced by interleukin-1<i>β</i> in Transwell chambers. After freeze-dried HYTB powder treatment, the percentage of T-cell subset and apoptosis rates of FLSs were measured using flow cytometry. Furthermore, protein e","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-19T19:08:06.116Z","creation":"2020-06-26T07:02:02Z"},"accession":"S-EPMC7256709","cross_references":{"pubmed":["32565847"],"doi":["10.1155/2020/1706837"]}}