{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(5)"],"submitter":["Tsai CW"],"funding":["Dr. Power Stem International Group"],"pubmed_abstract":["Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by two aggregates, namely, amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein (tau-p), which are released into the blood in a very small amount and cannot be easily detected. An increasing number of recent studies have suggested that S-glutathionylated glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is highly correlated with Aβ in patients with AD and that S-glutathionylated GAPDH plays a role as a proapoptotic factor in AD. We found that S-glutathionylated GAPDH is abundant in the blood of AD patients, which is unusual because S-glutathionylated GAPDH cannot exist in the blood under normal conditions. The aim of this study was to further explore the correlation betw"],"journal":["PloS one"],"pagination":["e0233289"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7259681"],"repository":["biostudies-literature"],"pubmed_title":["An investigation of the correlation between the S-glutathionylated GAPDH levels in blood and Alzheimer's disease progression."],"pmcid":["PMC7259681"],"pubmed_authors":["Tsai CW","Hsieh CC","Tsai CF","Lin CC","Lin KH","Chen WJ","Lin MS"],"additional_accession":[]},"is_claimable":false,"name":"An investigation of the correlation between the S-glutathionylated GAPDH levels in blood and Alzheimer's disease progression.","description":"Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by two aggregates, namely, amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein (tau-p), which are released into the blood in a very small amount and cannot be easily detected. An increasing number of recent studies have suggested that S-glutathionylated glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is highly correlated with Aβ in patients with AD and that S-glutathionylated GAPDH plays a role as a proapoptotic factor in AD. We found that S-glutathionylated GAPDH is abundant in the blood of AD patients, which is unusual because S-glutathionylated GAPDH cannot exist in the blood under normal conditions. The aim of this study was to further explore the correlation betw","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-22T16:46:42.558Z","creation":"2020-06-13T07:08:19Z"},"accession":"S-EPMC7259681","cross_references":{"pubmed":["32469899"],"doi":["10.1371/journal.pone.0233289"]}}