biostudies-literatureUnknown15(5)Tsai CWDr. Power Stem International GroupAlzheimer's disease (AD) is a progressive neurodegenerative disease characterized by two aggregates, namely, amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein (tau-p), which are released into the blood in a very small amount and cannot be easily detected. An increasing number of recent studies have suggested that S-glutathionylated glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is highly correlated with Aβ in patients with AD and that S-glutathionylated GAPDH plays a role as a proapoptotic factor in AD. We found that S-glutathionylated GAPDH is abundant in the blood of AD patients, which is unusual because S-glutathionylated GAPDH cannot exist in the blood under normal conditions. The aim of this study was to further explore the correlation betwPloS onee0233289https://www.ebi.ac.uk/biostudies/studies/S-EPMC7259681biostudies-literatureAn investigation of the correlation between the S-glutathionylated GAPDH levels in blood and Alzheimer's disease progression.PMC7259681Tsai CWHsieh CCTsai CFLin CCLin KHChen WJLin MSfalseAn investigation of the correlation between the S-glutathionylated GAPDH levels in blood and Alzheimer's disease progression.Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by two aggregates, namely, amyloid-β (Aβ) plaques and neurofibrillary tangles (NFTs) of hyperphosphorylated tau protein (tau-p), which are released into the blood in a very small amount and cannot be easily detected. An increasing number of recent studies have suggested that S-glutathionylated glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is highly correlated with Aβ in patients with AD and that S-glutathionylated GAPDH plays a role as a proapoptotic factor in AD. We found that S-glutathionylated GAPDH is abundant in the blood of AD patients, which is unusual because S-glutathionylated GAPDH cannot exist in the blood under normal conditions. The aim of this study was to further explore the correlation betw2020-01-01T00:00:00Z20202025-04-22T16:46:42.558Z2020-06-13T07:08:19ZS-EPMC72596813246989910.1371/journal.pone.0233289