biostudies-literatureUnknown37(2)Ma Y<h4>Introduction</h4>Previous studies found that vitamin D receptor (VDR) TaqI, BsmI, FokI and ApaI gene polymorphisms are associated with several inflammatory diseases. However, the relationship between VDR gene polymorphisms and chronic spontaneous urticaria (CSU) is not clear.<h4>Aim</h4>The purpose of our study was to explore the relationship between the polymorphism of VDR and the incidence of chronic spontaneous urticaria in the Chinese Han population. Meanwhile, the vitamin D levels in patients with chronic spontaneous urticaria were also detected and the effects of VDR gene polymorphism on vitamin D levels were detected.<h4>Material and methods</h4>The genotypes of four VDR polymorphisms (TaqI, BsmI, ApaI, and FokI) were studied using allele-specific PCR analysis in 90 CSU patients and 90 healthy controls.<h4>Results</h4>Compared to the control group, the mutant allele (C) of FokI were more common in patients with CSU (57.2% vs. 45%, <i>p</i> = 0.020, odds ratio (OR) = 0.612, 95% confidence interval (CI): 0.403-0.928). We found that serum vitamin D levels were significantly lower in CSU patients than in healthy controls (<i>p</i> = 0.023). However, the effect of VDR gene polymorphism on vitamin D levels was not found in patients of CSU.<h4>Conclusions</h4>We first reported the effect of VDR gene FokI (rs2228570) polymorphism on the incidence of chronic spontaneous urticaria in the Chinese Han population.Postepy dermatologii i alergologii250-254https://www.ebi.ac.uk/biostudies/studies/S-EPMC7262806biostudies-literatureAssociations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population.PMC7262806Wu JCui PLi CXiang ZMa YYao XFeng SLin LfalseAssociations between vitamin D receptor gene polymorphisms and chronic spontaneous urticaria in Chinese Han population.<h4>Introduction</h4>Previous studies found that vitamin D receptor (VDR) TaqI, BsmI, FokI and ApaI gene polymorphisms are associated with several inflammatory diseases. However, the relationship between VDR gene polymorphisms and chronic spontaneous urticaria (CSU) is not clear.<h4>Aim</h4>The purpose of our study was to explore the relationship between the polymorphism of VDR and the incidence of chronic spontaneous urticaria in the Chinese Han population. Meanwhile, the vitamin D levels in patients with chronic spontaneous urticaria were also detected and the effects of VDR gene polymorphism on vitamin D levels were detected.<h4>Material and methods</h4>The genotypes of four VDR polymorphisms (TaqI, BsmI, ApaI, and FokI) were studied using allele-specific PCR analysis in 90 CSU patients and 90 healthy controls.<h4>Results</h4>Compared to the control group, the mutant allele (C) of FokI were more common in patients with CSU (57.2% vs. 45%, <i>p</i> = 0.020, odds ratio (OR) = 0.612, 95% confidence interval (CI): 0.403-0.928). We found that serum vitamin D levels were significantly lower in CSU patients than in healthy controls (<i>p</i> = 0.023). However, the effect of VDR gene polymorphism on vitamin D levels was not found in patients of CSU.<h4>Conclusions</h4>We first reported the effect of VDR gene FokI (rs2228570) polymorphism on the incidence of chronic spontaneous urticaria in the Chinese Han population.2020-01-01T00:00:00Z2020 Apr2024-02-15T13:25:08.425Z2020-06-05T07:08:21ZS-EPMC72628063248936210.5114/ada.2020.94843