{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu J"],"funding":["“Double First-Class” University project","China National Nature Science Foundation","six talent peaks project in Jiangsu Province","Leading technology foundation research project of Jiangsu Province","China Postdoctoral Science Found","National Research Council of Science and Technology Major Project of China","Major State Basic Research Development Program of China"],"pagination":["101452"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7264470"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32"],"pubmed_abstract":["Improving the limited penetration, accumulation and therapeutic effects of antitumor drugs in the avascular region of the tumor mass is crucial during chemotherapy. P-gp inhibitors have achieved little success despite significant efforts. Excessive P-gp inhibition disturbed the kinetic balance between intracellular accumulation and intercellular penetration, thus resulting in a more inhomogeneous distribution of substrate drugs. Here, we found that ginsenoside Rh2 pretreatment mildly downregulated P-gp expression through reactivating the pentose phosphate pathway and rebalancing redox status. This mild P-gp inhibition not only significantly increased the growth inhibition effect and accumulation profile of adriamycin (ADR) throughout the multicellular tumor spheroid (MCTS) but also had uni"],"journal":["Redox biology"],"pubmed_title":["Ginsenoside Rh2 pretreatment and withdrawal reactivated the pentose phosphate pathway to ameliorate intracellular redox disturbance and promoted intratumoral penetration of adriamycin."],"pmcid":["PMC7264470"],"funding_grant_id":["2018M642374","2019ZX09721001-006-005","2017ZX09201004-019","2017YFA0205400","YY-060","81803625","BK20192005","2019ZX09302023","81773989","BK20180558","CPU2018GF01","81703600"],"pubmed_authors":["Cai Q","Sun M","Liu J","Lu M","Zhang J","Wang W","Wang G","Zhou F"],"additional_accession":[]},"is_claimable":false,"name":"Ginsenoside Rh2 pretreatment and withdrawal reactivated the pentose phosphate pathway to ameliorate intracellular redox disturbance and promoted intratumoral penetration of adriamycin.","description":"Improving the limited penetration, accumulation and therapeutic effects of antitumor drugs in the avascular region of the tumor mass is crucial during chemotherapy. P-gp inhibitors have achieved little success despite significant efforts. Excessive P-gp inhibition disturbed the kinetic balance between intracellular accumulation and intercellular penetration, thus resulting in a more inhomogeneous distribution of substrate drugs. Here, we found that ginsenoside Rh2 pretreatment mildly downregulated P-gp expression through reactivating the pentose phosphate pathway and rebalancing redox status. This mild P-gp inhibition not only significantly increased the growth inhibition effect and accumulation profile of adriamycin (ADR) throughout the multicellular tumor spheroid (MCTS) but also had uni","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2025-04-19T11:49:29.03Z","creation":"2020-06-09T07:12:12Z"},"accession":"S-EPMC7264470","cross_references":{"pubmed":["32067911"],"doi":["10.1016/j.redox.2020.101452"]}}