{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ribeiro FC"],"funding":["DOD | United States Navy | Office of Naval Research","Brown-Brazil Initiative","COBRE-NIH","MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico","Fundação de Amparo à Pesquisa do Estado de São Paulo"],"pagination":["e02323-19"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7269487"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(6)"],"pubmed_abstract":["Probiotics might provide an alternative approach for the control of oral candidiasis. However, studies on the antifungal activity of probiotics in the oral cavity are based on the consumption of yogurt or other dietary products, and it is necessary to use appropriate biomaterials and specific strains to obtain probiotic formulations targeted for local oral administration. In this study, we impregnated gellan gum, a natural biopolymer used as a food additive, with a probiotic and investigated its antifungal activity against Candida albicansLactobacillus paracasei 28.4, a strain recently isolated from the oral cavity of a caries-free individual, was incorporated in several concentrations of gellan gum (0.6% to 1% [wt/vol]). All tested concentrations could incorporate L. paracasei cells while"],"journal":["Antimicrobial agents and chemotherapy"],"pubmed_title":["Development of Probiotic Formulations for Oral Candidiasis Prevention: Gellan Gum as a Carrier To Deliver Lactobacillus paracasei 28.4."],"pmcid":["PMC7269487"],"funding_grant_id":["306330/2018-0","N000141712651","P20 GM103430","N000141712120","2016/25544-1"],"pubmed_authors":["Mylonakis E","Shukla S","Ribeiro FC","Shukla A","Fuchs BB","Dos Santos JD","Rossoni RD","de Barros PP","Junqueira JC"],"additional_accession":[]},"is_claimable":false,"name":"Development of Probiotic Formulations for Oral Candidiasis Prevention: Gellan Gum as a Carrier To Deliver Lactobacillus paracasei 28.4.","description":"Probiotics might provide an alternative approach for the control of oral candidiasis. However, studies on the antifungal activity of probiotics in the oral cavity are based on the consumption of yogurt or other dietary products, and it is necessary to use appropriate biomaterials and specific strains to obtain probiotic formulations targeted for local oral administration. In this study, we impregnated gellan gum, a natural biopolymer used as a food additive, with a probiotic and investigated its antifungal activity against Candida albicansLactobacillus paracasei 28.4, a strain recently isolated from the oral cavity of a caries-free individual, was incorporated in several concentrations of gellan gum (0.6% to 1% [wt/vol]). All tested concentrations could incorporate L. paracasei cells while","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2025-04-05T14:00:10.088Z","creation":"2021-02-19T11:48:59Z"},"accession":"S-EPMC7269487","cross_references":{"pubmed":["32253208"],"doi":["10.1128/aac.02323-19","10.1128/AAC.02323-19"]}}