{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sato E"],"funding":["National Institute of Environmental Health Sciences","John J. Godleski MD PLLC","NIEHS NIH HHS"],"pagination":["20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7271432"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["<h4>Background</h4>Talc, a hydrous magnesium silicate, often used for genital hygiene purposes, is associated with ovarian carcinoma in case-control studies. Its potential to cause inflammation, injury, and functional changes in cells has been described. A complication of such studies is that talc preparations may be contaminated with other materials. A previous study by (Beck et al. Toxicol Appl Pharmacol 87:222-34, 1987) used a hamster model to study talc and granite dust exposure effects on various biochemical and cellular inflammatory markers. Our current study accessed key materials used in that 1987 study; we re-analyzed the original talc dust with contemporary scanning electron microscopy and energy dispersive x-ray analysis (SEM/EDX) for contaminants. We also examined the original "],"journal":["Particle and fibre toxicology"],"pubmed_title":["Analysis of particles from hamster lungs following pulmonary talc exposures: implications for pathogenicity."],"pmcid":["PMC7271432"],"funding_grant_id":["Not applicable","ES-00002"],"pubmed_authors":["Brain JD","Sato E","McDonald SA","Godleski JJ","Fan Y","Peterson S"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of particles from hamster lungs following pulmonary talc exposures: implications for pathogenicity.","description":"<h4>Background</h4>Talc, a hydrous magnesium silicate, often used for genital hygiene purposes, is associated with ovarian carcinoma in case-control studies. Its potential to cause inflammation, injury, and functional changes in cells has been described. A complication of such studies is that talc preparations may be contaminated with other materials. A previous study by (Beck et al. Toxicol Appl Pharmacol 87:222-34, 1987) used a hamster model to study talc and granite dust exposure effects on various biochemical and cellular inflammatory markers. Our current study accessed key materials used in that 1987 study; we re-analyzed the original talc dust with contemporary scanning electron microscopy and energy dispersive x-ray analysis (SEM/EDX) for contaminants. We also examined the original ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-19T04:36:00.076Z","creation":"2020-06-13T07:11:52Z"},"accession":"S-EPMC7271432","cross_references":{"pubmed":["32498698"],"doi":["10.1186/s12989-020-00356-0"]}}