biostudies-literatureSato ENational Institute of Environmental Health SciencesJohn J. Godleski MD PLLCNIEHS NIH HHS20https://www.ebi.ac.uk/biostudies/studies/S-EPMC7271432biostudies-literatureUnknown17(1)<h4>Background</h4>Talc, a hydrous magnesium silicate, often used for genital hygiene purposes, is associated with ovarian carcinoma in case-control studies. Its potential to cause inflammation, injury, and functional changes in cells has been described. A complication of such studies is that talc preparations may be contaminated with other materials. A previous study by (Beck et al. Toxicol Appl Pharmacol 87:222-34, 1987) used a hamster model to study talc and granite dust exposure effects on various biochemical and cellular inflammatory markers. Our current study accessed key materials used in that 1987 study; we re-analyzed the original talc dust with contemporary scanning electron microscopy and energy dispersive x-ray analysis (SEM/EDX) for contaminants. We also examined the original Particle and fibre toxicologyAnalysis of particles from hamster lungs following pulmonary talc exposures: implications for pathogenicity.PMC7271432Not applicableES-00002Brain JDSato EMcDonald SAGodleski JJFan YPeterson SfalseAnalysis of particles from hamster lungs following pulmonary talc exposures: implications for pathogenicity.<h4>Background</h4>Talc, a hydrous magnesium silicate, often used for genital hygiene purposes, is associated with ovarian carcinoma in case-control studies. Its potential to cause inflammation, injury, and functional changes in cells has been described. A complication of such studies is that talc preparations may be contaminated with other materials. A previous study by (Beck et al. Toxicol Appl Pharmacol 87:222-34, 1987) used a hamster model to study talc and granite dust exposure effects on various biochemical and cellular inflammatory markers. Our current study accessed key materials used in that 1987 study; we re-analyzed the original talc dust with contemporary scanning electron microscopy and energy dispersive x-ray analysis (SEM/EDX) for contaminants. We also examined the original 2020-01-01T00:00:00Z2020 Jun2025-04-19T04:36:00.076Z2020-06-13T07:11:52ZS-EPMC72714323249869810.1186/s12989-020-00356-0