biostudies-literature00480UnknownNg DLWe report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors. We additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobulin-M, and in vitro neutralizing antibody titers in COVID-19 patients. Neutralizing antibodies rise in tandem with immunoglobulin levels following symptom onset, exhibiting median time to seroconversion within one day of each other, and there is >93% positive percent agreement between detection of immunoglobulin-G and neutralizing titers.medRxiv : the preprint server for health sciences2020.05.19.20107482https://www.ebi.ac.uk/biostudies/studies/S-EPMC7273245biostudies-literatureSARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area.PMC7273245Truong KWang CSotomayor-Gonzalez AMiller SColler KQazi DGoldgof GMAlazzeh FLevine AGNg DLStone MWilliamson PHackett JNeumann NMPham LGlasner DRHills NKHakim JMCSujishi KShy BRSantos YAHsu ELu CMPillai SKWhitman JDBalcerek JGu WSimmons GStramer SHan LMNguyen DNBapat SPServellita VReyes KProstko JGranados AFranz SChiu CYPearce SAkagi NCuster BOon CYKurtz TRodgers MMartin CSSGreen VBusch MPDu L48falseSARS-CoV-2 seroprevalence and neutralizing activity in donor and patient blood from the San Francisco Bay Area.We report very low SARS-CoV-2 seroprevalence in two San Francisco Bay Area populations. Seropositivity was 0.26% in 387 hospitalized patients admitted for non-respiratory indications and 0.1% in 1,000 blood donors. We additionally describe the longitudinal dynamics of immunoglobulin-G, immunoglobulin-M, and in vitro neutralizing antibody titers in COVID-19 patients. Neutralizing antibodies rise in tandem with immunoglobulin levels following symptom onset, exhibiting median time to seroconversion within one day of each other, and there is >93% positive percent agreement between detection of immunoglobulin-G and neutralizing titers.2020-01-01T00:00:00Z2020 May2024-11-10T01:27:56.616Z2020-06-14T07:09:20ZS-EPMC72732453251147710.1101/2020.05.19.20107482