biostudies-literatureSaadouli IGerman Academic Exchange ServiceE270https://www.ebi.ac.uk/biostudies/studies/S-EPMC7277807biostudies-literatureUnknown9(5)Streptomyces is the most frequently described genus of Actinomycetes, a producer of biologically active secondary metabolites. Indeed, the Streptomyces species produces about 70% of antibiotics and 60% of antifungal molecules used in agriculture. Our study was carried out with the goal of isolating and identifying antimicrobial secondary metabolites from Streptomyces misionensisV16R3Y1 isolated from the date palm rhizosphere (southern Tunisia). This strain presented a broad range of antifungal activity against Fusariumoxysporum, Aspergillusflavus, Penicilliumexpansum, Aspergillusniger, Candida albicans, Candidametapsilosis, and Candidaparapsilosis and antibacterial activity against human pathogenic bacteria, including Escherichiafergusonii, Staphylococcus aureus, Salmonella enterica, EnterAntibiotics (Basel, Switzerland)Isolation, Characterization and Chemical Synthesis of Large Spectrum Antimicrobial Cyclic Dipeptide (l-leu-l-pro) from Streptomyces misionensisV16R3Y1 Bacteria Extracts. A Novel 1H NMR Metabolomic Approach.PMC7277807ID57166072Saadouli IFhoula IOuzari HISewald NSabatier JMMosbah ACherif AFerjani RTrabelsi ERedissi AZendah El Euch IfalseIsolation, Characterization and Chemical Synthesis of Large Spectrum Antimicrobial Cyclic Dipeptide (l-leu-l-pro) from Streptomyces misionensisV16R3Y1 Bacteria Extracts. A Novel 1H NMR Metabolomic Approach.Streptomyces is the most frequently described genus of Actinomycetes, a producer of biologically active secondary metabolites. Indeed, the Streptomyces species produces about 70% of antibiotics and 60% of antifungal molecules used in agriculture. Our study was carried out with the goal of isolating and identifying antimicrobial secondary metabolites from Streptomyces misionensisV16R3Y1 isolated from the date palm rhizosphere (southern Tunisia). This strain presented a broad range of antifungal activity against Fusariumoxysporum, Aspergillusflavus, Penicilliumexpansum, Aspergillusniger, Candida albicans, Candidametapsilosis, and Candidaparapsilosis and antibacterial activity against human pathogenic bacteria, including Escherichiafergusonii, Staphylococcus aureus, Salmonella enterica, Enter2020-01-01T00:00:00Z2020 May2025-04-04T03:25:10.096Z2020-06-17T07:03:16ZS-EPMC72778073245578410.3390/antibiotics9050270