{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Markov AV"],"funding":["Russian State funded budget project of ICBFM SB RAS","Russian Foundation for Basic Research","Russian Science Foundation"],"pagination":["E3511"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7279002"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(10)"],"pubmed_abstract":["A series of novel 18βH-glycyrrhetinic acid (GA) derivatives containing 3'-(alkyl/phenyl/pyridin(-2″, -3″, and -4″)-yl)-1',2',4'-oxadiazole moieties at the C-30 position were synthesized by condensation of triterpenoid's carboxyl group with corresponding amidoximes and further cyclization. Screening of the cytotoxicity of novel GA derivatives on a panel of tumor cell lines showed that the 3-acetoxy triterpenoid intermediates-<i>O</i>-acylated amidoxime <b>3a-h</b>-display better solubility under bioassay conditions and more pronounced cytotoxicity compared to their 1',2',4'-oxadiazole analogs <b>4f-h</b> (median IC<sub>50</sub> = 7.0 and 49.7 µM, respectively). Subsequent replacement of the 3-acetoxy group by the hydroxyl group of pyridin(-2″, 3″, and -4″)-yl-1',2',4'-oxadiazole-bearing GA "],"journal":["International journal of molecular sciences"],"pubmed_title":["Novel 3'-Substituted-1',2',4'-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their <i>O</i>-Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo."],"pmcid":["PMC7279002"],"funding_grant_id":["AAAA-A17-117020210024-8","16-33-00414","17-75-20120"],"pubmed_authors":["Zenkova MA","Komarova NI","Logashenko EB","Ilyina AA","Markov AV","Salomatina OV","Popadyuk II","Salakhutdinov NF","Sen'kova AV"],"additional_accession":[]},"is_claimable":false,"name":"Novel 3'-Substituted-1',2',4'-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their <i>O</i>-Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo.","description":"A series of novel 18βH-glycyrrhetinic acid (GA) derivatives containing 3'-(alkyl/phenyl/pyridin(-2″, -3″, and -4″)-yl)-1',2',4'-oxadiazole moieties at the C-30 position were synthesized by condensation of triterpenoid's carboxyl group with corresponding amidoximes and further cyclization. Screening of the cytotoxicity of novel GA derivatives on a panel of tumor cell lines showed that the 3-acetoxy triterpenoid intermediates-<i>O</i>-acylated amidoxime <b>3a-h</b>-display better solubility under bioassay conditions and more pronounced cytotoxicity compared to their 1',2',4'-oxadiazole analogs <b>4f-h</b> (median IC<sub>50</sub> = 7.0 and 49.7 µM, respectively). Subsequent replacement of the 3-acetoxy group by the hydroxyl group of pyridin(-2″, 3″, and -4″)-yl-1',2',4'-oxadiazole-bearing GA ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 May","modification":"2026-04-08T01:56:09.117Z","creation":"2020-06-20T07:06:44Z"},"accession":"S-EPMC7279002","cross_references":{"pubmed":["32429154"],"doi":["10.3390/ijms21103511"]}}