biostudies-literatureUnknown36(3)Solimene FWe report the use of the new automated tool Lumipoint^TM for the detection of LAVA (local abnormal ventricular activities) when they are buried within the far-field ventricular signal, especially in regions of preserved myocardial thickness, such as the left ventricular (LV) septum. The LV substrate and the tachycardia circuit during ventricular tachycardias of a 60-year-old man with dilated cardiomyopathy were mapped using an ultra-high-density mapping system and then the Lumipoint^TM, analyzing the EGMs of interest, identified the LAVA in the inferoseptal region. This algorithm may be helpful to quickly target the septal substrate avoiding misleading interpretation.Journal of arrhythmia528-531https://www.ebi.ac.uk/biostudies/studies/S-EPMC7279972biostudies-literatureHow to unmask septal local abnormal ventricular activities with the new LUMIPOINT^TM software.PMC7279972Solimene FMaddaluno FMalacrida MStabile GfalseHow to unmask septal local abnormal ventricular activities with the new LUMIPOINT^TM software.We report the use of the new automated tool Lumipoint^TM for the detection of LAVA (local abnormal ventricular activities) when they are buried within the far-field ventricular signal, especially in regions of preserved myocardial thickness, such as the left ventricular (LV) septum. The LV substrate and the tachycardia circuit during ventricular tachycardias of a 60-year-old man with dilated cardiomyopathy were mapped using an ultra-high-density mapping system and then the Lumipoint^TM, analyzing the EGMs of interest, identified the LAVA in the inferoseptal region. This algorithm may be helpful to quickly target the septal substrate avoiding misleading interpretation.2020-01-01T00:00:00Z2020 Jun2025-04-04T12:08:29.83Z2020-06-14T07:09:44ZS-EPMC72799723252858310.1002/joa3.12344