{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Steunou AS"],"pubmed_abstract":["Cadmium, although not redox active is highly toxic. Yet, the underlying mechanisms driving toxicity are still to be characterized. In this study, we took advantage of the purple bacterium <i>Rubrivivax gelatinosus</i> strain with defective Cd<sup>2 +</sup>-efflux system to identify targets of this metal. Exposure of the Δ<i>cadA</i> strain to Cd<sup>2 +</sup> causes a decrease in the photosystem amount and in the activity of respiratory complexes. As in case of Cu<sup>+</sup> toxicity, the data indicated that Cd<sup>2 +</sup> targets the porphyrin biosynthesis pathway at the level of HemN, a <i>S</i>-adenosylmethionine and CxxxCxxC coordinated [4Fe-4S] containing enzyme. Cd<sup>2 +</sup> exposure therefore results in a deficiency in heme and chlorophyll dependent proteins and metabolic pat"],"journal":["Frontiers in microbiology"],"pagination":["893"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7283390"],"repository":["biostudies-literature"],"pubmed_title":["Cadmium and Copper Cross-Tolerance. Cu<sup>+</sup> Alleviates Cd<sup>2 +</sup> Toxicity, and Both Cations Target Heme and Chlorophyll Biosynthesis Pathway in <i>Rubrivivax gelatinosus</i>."],"pmcid":["PMC7283390"],"pubmed_authors":["Ouchane S","Steunou AS","Durand A","Bourbon ML","Liotenberg S","Babot M","Tambosi R"],"additional_accession":[]},"is_claimable":false,"name":"Cadmium and Copper Cross-Tolerance. Cu<sup>+</sup> Alleviates Cd<sup>2 +</sup> Toxicity, and Both Cations Target Heme and Chlorophyll Biosynthesis Pathway in <i>Rubrivivax gelatinosus</i>.","description":"Cadmium, although not redox active is highly toxic. Yet, the underlying mechanisms driving toxicity are still to be characterized. In this study, we took advantage of the purple bacterium <i>Rubrivivax gelatinosus</i> strain with defective Cd<sup>2 +</sup>-efflux system to identify targets of this metal. Exposure of the Δ<i>cadA</i> strain to Cd<sup>2 +</sup> causes a decrease in the photosystem amount and in the activity of respiratory complexes. As in case of Cu<sup>+</sup> toxicity, the data indicated that Cd<sup>2 +</sup> targets the porphyrin biosynthesis pathway at the level of HemN, a <i>S</i>-adenosylmethionine and CxxxCxxC coordinated [4Fe-4S] containing enzyme. Cd<sup>2 +</sup> exposure therefore results in a deficiency in heme and chlorophyll dependent proteins and metabolic pat","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-06-01T03:00:36.736Z","creation":"2025-06-01T03:00:36.736Z"},"accession":"S-EPMC7283390","cross_references":{"pubmed":["32582041"],"doi":["10.3389/fmicb.2020.00893"]}}