{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(2)"],"submitter":["Mazeraud A"],"pubmed_abstract":["Septic-associated encephalopathy (SAE) is a key manifestation of sepsis, ranging from delirium to coma and occurring in up to 70% of patients admitted to the ICU. SAE is associated with higher ICU and hospital mortality, and also with poorer long-term outcomes, including cognitive and functional outcomes. The pathophysiology of SAE is complex, and it may involve neurotransmitter dysfunction, inflammatory and ischemic lesions to the brain, microglial activation, and blood-brain barrier dysfunction. Delirium (which is included in the SAE spectrum) is mostly diagnosed with validated scales in the ICU population. There is no established treatment for SAE; benzodiazepines should generally be avoided in this setting. Nonpharmacological prevention and management is key for treating SAE; it includ"],"journal":["Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics"],"pagination":["392-403"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7283452"],"repository":["biostudies-literature"],"pubmed_title":["Septic-Associated Encephalopathy: a Comprehensive Review."],"pmcid":["PMC7283452"],"pubmed_authors":["Mazeraud A","Bozza FA","Bouchereau E","Benghanem S","Sharshar T","Righy C"],"additional_accession":[]},"is_claimable":false,"name":"Septic-Associated Encephalopathy: a Comprehensive Review.","description":"Septic-associated encephalopathy (SAE) is a key manifestation of sepsis, ranging from delirium to coma and occurring in up to 70% of patients admitted to the ICU. SAE is associated with higher ICU and hospital mortality, and also with poorer long-term outcomes, including cognitive and functional outcomes. The pathophysiology of SAE is complex, and it may involve neurotransmitter dysfunction, inflammatory and ischemic lesions to the brain, microglial activation, and blood-brain barrier dysfunction. Delirium (which is included in the SAE spectrum) is mostly diagnosed with validated scales in the ICU population. There is no established treatment for SAE; benzodiazepines should generally be avoided in this setting. Nonpharmacological prevention and management is key for treating SAE; it includ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2025-04-22T00:48:17.783Z","creation":"2022-02-09T10:13:16.385Z"},"accession":"S-EPMC7283452","cross_references":{"pubmed":["32378026"],"doi":["10.1007/s13311-020-00862-1"]}}