{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nair S"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["E657"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7285187"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(5)"],"pubmed_abstract":["<i>Salmonella enterica</i> with the identical antigenic formula 6,7:c:1,5 can be differentiated biochemically and by disease syndrome. One grouping, <i>Salmonella</i> Paratyphi C, is currently considered a typhoidal serovar, responsible for enteric fever in humans. The human-restricted typhoidal serovars (<i>S.</i> Typhi and Paratyphi A, B and C) typically display high levels of genome degradation and are cited as an example of convergent evolution for host adaptation in humans. However, <i>S.</i> Paratyphi C presents a different clinical picture to <i>S.</i> Typhi/Paratyphi A, in a patient group with predisposition, raising the possibility that its natural history is different, and that infection is invasive salmonellosis rather than enteric fever. Using whole genome sequencing and metabo"],"journal":["Microorganisms"],"pubmed_title":["Genetic Markers in <i>S.</i> Paratyphi C Reveal Primary Adaptation to Pigs."],"pmcid":["PMC7285187"],"funding_grant_id":["BBS/E/F/000PR10352","BB/R012504/1","BBS/E/F/000PR10349"],"pubmed_authors":["Corton C","Langridge GC","Fookes M","Wain J","Nair S","Thomson NR"],"additional_accession":[]},"is_claimable":false,"name":"Genetic Markers in <i>S.</i> Paratyphi C Reveal Primary Adaptation to Pigs.","description":"<i>Salmonella enterica</i> with the identical antigenic formula 6,7:c:1,5 can be differentiated biochemically and by disease syndrome. One grouping, <i>Salmonella</i> Paratyphi C, is currently considered a typhoidal serovar, responsible for enteric fever in humans. The human-restricted typhoidal serovars (<i>S.</i> Typhi and Paratyphi A, B and C) typically display high levels of genome degradation and are cited as an example of convergent evolution for host adaptation in humans. However, <i>S.</i> Paratyphi C presents a different clinical picture to <i>S.</i> Typhi/Paratyphi A, in a patient group with predisposition, raising the possibility that its natural history is different, and that infection is invasive salmonellosis rather than enteric fever. Using whole genome sequencing and metabo","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Apr","modification":"2026-04-07T22:39:56.554Z","creation":"2020-06-25T07:28:22Z"},"accession":"S-EPMC7285187","cross_references":{"pubmed":["32365926"],"doi":["10.3390/microorganisms8050657"]}}