biostudies-literatureNair SBiotechnology and Biological Sciences Research CouncilE657https://www.ebi.ac.uk/biostudies/studies/S-EPMC7285187biostudies-literatureUnknown8(5)<i>Salmonella enterica</i> with the identical antigenic formula 6,7:c:1,5 can be differentiated biochemically and by disease syndrome. One grouping, <i>Salmonella</i> Paratyphi C, is currently considered a typhoidal serovar, responsible for enteric fever in humans. The human-restricted typhoidal serovars (<i>S.</i> Typhi and Paratyphi A, B and C) typically display high levels of genome degradation and are cited as an example of convergent evolution for host adaptation in humans. However, <i>S.</i> Paratyphi C presents a different clinical picture to <i>S.</i> Typhi/Paratyphi A, in a patient group with predisposition, raising the possibility that its natural history is different, and that infection is invasive salmonellosis rather than enteric fever. Using whole genome sequencing and metaboMicroorganismsGenetic Markers in <i>S.</i> Paratyphi C Reveal Primary Adaptation to Pigs.PMC7285187BBS/E/F/000PR10352BB/R012504/1BBS/E/F/000PR10349Corton CLangridge GCFookes MWain JNair SThomson NRfalseGenetic Markers in <i>S.</i> Paratyphi C Reveal Primary Adaptation to Pigs.<i>Salmonella enterica</i> with the identical antigenic formula 6,7:c:1,5 can be differentiated biochemically and by disease syndrome. One grouping, <i>Salmonella</i> Paratyphi C, is currently considered a typhoidal serovar, responsible for enteric fever in humans. The human-restricted typhoidal serovars (<i>S.</i> Typhi and Paratyphi A, B and C) typically display high levels of genome degradation and are cited as an example of convergent evolution for host adaptation in humans. However, <i>S.</i> Paratyphi C presents a different clinical picture to <i>S.</i> Typhi/Paratyphi A, in a patient group with predisposition, raising the possibility that its natural history is different, and that infection is invasive salmonellosis rather than enteric fever. Using whole genome sequencing and metabo2020-01-01T00:00:00Z2020 Apr2026-04-07T22:39:56.554Z2020-06-25T07:28:22ZS-EPMC72851873236592610.3390/microorganisms8050657