{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shen S"],"funding":["Natural Science Foundation of Zhejiang Province","National Natural Science Foundation of China"],"pagination":["23"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7285530"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["<h4>Background</h4>Genetic research on longevity has provided important insights into the mechanism of aging and aging-related diseases. Pinpointing import genetic variants associated with aging could provide insights for aging research.<h4>Methods</h4>We performed a whole-genome sequencing in 19 centenarians to establish the genetic basis of human longevity.<h4>Results</h4>Using SKAT analysis, we found 41 significantly correlated genes in centenarians as compared to control genomes. Pathway enrichment analysis of these genes showed that immune-related pathways were enriched, suggesting that immune pathways might be critically involved in aging. HLA typing was next performed based on the whole-genome sequencing data obtained. We discovered that several HLA subtypes were significantly overr"],"journal":["Human genomics"],"pubmed_title":["Whole-genome sequencing of Chinese centenarians reveals important genetic variants in aging WGS of centenarian for genetic analysis of aging."],"pmcid":["PMC7285530"],"funding_grant_id":["no. 81503527","ZZYJ-WTRW-2018-01"],"pubmed_authors":["Li Y","Li C","Xiao L","Lv H","Shen S","Wang X","Huang Q","Shi Y"],"additional_accession":[]},"is_claimable":false,"name":"Whole-genome sequencing of Chinese centenarians reveals important genetic variants in aging WGS of centenarian for genetic analysis of aging.","description":"<h4>Background</h4>Genetic research on longevity has provided important insights into the mechanism of aging and aging-related diseases. Pinpointing import genetic variants associated with aging could provide insights for aging research.<h4>Methods</h4>We performed a whole-genome sequencing in 19 centenarians to establish the genetic basis of human longevity.<h4>Results</h4>Using SKAT analysis, we found 41 significantly correlated genes in centenarians as compared to control genomes. Pathway enrichment analysis of these genes showed that immune-related pathways were enriched, suggesting that immune pathways might be critically involved in aging. HLA typing was next performed based on the whole-genome sequencing data obtained. We discovered that several HLA subtypes were significantly overr","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-05-29T19:18:56.28Z","creation":"2025-05-29T19:18:56.28Z"},"accession":"S-EPMC7285530","cross_references":{"pubmed":["32522283"],"doi":["10.1186/s40246-020-00271-7"]}}