biostudies-literatureShen SNatural Science Foundation of Zhejiang ProvinceNational Natural Science Foundation of China23https://www.ebi.ac.uk/biostudies/studies/S-EPMC7285530biostudies-literatureUnknown14(1)<h4>Background</h4>Genetic research on longevity has provided important insights into the mechanism of aging and aging-related diseases. Pinpointing import genetic variants associated with aging could provide insights for aging research.<h4>Methods</h4>We performed a whole-genome sequencing in 19 centenarians to establish the genetic basis of human longevity.<h4>Results</h4>Using SKAT analysis, we found 41 significantly correlated genes in centenarians as compared to control genomes. Pathway enrichment analysis of these genes showed that immune-related pathways were enriched, suggesting that immune pathways might be critically involved in aging. HLA typing was next performed based on the whole-genome sequencing data obtained. We discovered that several HLA subtypes were significantly overrHuman genomicsWhole-genome sequencing of Chinese centenarians reveals important genetic variants in aging WGS of centenarian for genetic analysis of aging.PMC7285530no. 81503527ZZYJ-WTRW-2018-01Li YLi CXiao LLv HShen SWang XHuang QShi YfalseWhole-genome sequencing of Chinese centenarians reveals important genetic variants in aging WGS of centenarian for genetic analysis of aging.<h4>Background</h4>Genetic research on longevity has provided important insights into the mechanism of aging and aging-related diseases. Pinpointing import genetic variants associated with aging could provide insights for aging research.<h4>Methods</h4>We performed a whole-genome sequencing in 19 centenarians to establish the genetic basis of human longevity.<h4>Results</h4>Using SKAT analysis, we found 41 significantly correlated genes in centenarians as compared to control genomes. Pathway enrichment analysis of these genes showed that immune-related pathways were enriched, suggesting that immune pathways might be critically involved in aging. HLA typing was next performed based on the whole-genome sequencing data obtained. We discovered that several HLA subtypes were significantly overr2020-01-01T00:00:00Z2020 Jun2025-05-29T19:18:56.28Z2025-05-29T19:18:56.28ZS-EPMC72855303252228310.1186/s40246-020-00271-7