{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Prakash J"],"funding":["Skåne University Hospital","H Järnhardt Foundation","Albert Påhlsson Foundation","King Gustav V and Queen Victoria Foundation","Swedish Research Council","Alfred Österlunds Foundation","Swedish Rheumatism Association","Research and Development Council of Region Skåne","Greta and Johan Kock Foundation"],"pagination":["100009"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7286079"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2"],"pubmed_abstract":["<h4>Background and aim</h4>The Receptor Activity Modifying Proteins (RAMPs) are a group of accessory proteins, of which there are three in humans, that interact with a number of G-protein coupled receptors (GPCR) and play various roles in regulation of endocrine signaling. Studies in RAMP3 knockout (KO) mice reveal an age related phenotype with altered metabolic regulation and high bone mass. To translate these findings into a clinically relevant perspective, we investigated the association between <i>RAMP3</i> gene variants, body composition and bone phenotypes in two population-based cohorts of Swedish women.<h4>Methods</h4>Five single nucleotide polymorphisms (SNP) in the vicinity of the RAMP3 gene were genotyped in the PEAK-25 cohort (n = 1061; 25 years) and OPRA (n = 1044; 75 years). "],"journal":["Gene: X"],"pubmed_title":["Analysis of RAMP3 gene polymorphism with body composition and bone density in young and elderly women."],"pmcid":["PMC7286079"],"funding_grant_id":["K2015-52X-14691-13-4"],"pubmed_authors":["Richards GO","Garg G","Skerry TM","Kumar J","McGuigan FEA","Grabowski PS","Prakash J","Herlin M","Akesson KE"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of RAMP3 gene polymorphism with body composition and bone density in young and elderly women.","description":"<h4>Background and aim</h4>The Receptor Activity Modifying Proteins (RAMPs) are a group of accessory proteins, of which there are three in humans, that interact with a number of G-protein coupled receptors (GPCR) and play various roles in regulation of endocrine signaling. Studies in RAMP3 knockout (KO) mice reveal an age related phenotype with altered metabolic regulation and high bone mass. To translate these findings into a clinically relevant perspective, we investigated the association between <i>RAMP3</i> gene variants, body composition and bone phenotypes in two population-based cohorts of Swedish women.<h4>Methods</h4>Five single nucleotide polymorphisms (SNP) in the vicinity of the RAMP3 gene were genotyped in the PEAK-25 cohort (n = 1061; 25 years) and OPRA (n = 1044; 75 years). ","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2026-05-05T06:30:55.881Z","creation":"2020-06-20T07:10:10Z"},"accession":"S-EPMC7286079","cross_references":{"pubmed":["32550545"],"doi":["10.1016/j.gene.2019.100009"]}}