{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Cha H"],"funding":["Natural Science Foundation of Guangdong Province","National Natural Science Foundation of China"],"pubmed_abstract":["Many kinds of lymphocytes are involved in <i>Schistosoma japonicum</i> (<i>S. japonicum</i>) infection-induced disease. γδ T cells comprise a small number of innate lymphocytes that quickly respond to foreign materials. In this study, the role of γδ T cells in the lung of <i>S. japonicum</i>-infected C56BL/6 mice was investigated. The results demonstrated that <i>S. japonicum</i> infection induces γδ T cell accumulation in the lung, expressing higher levels of CD25, MHCII, CD80, and PDL1, and lower levels of CD127 and CD62L (<i>P</i> < 0.05). The intracellular cytokines staining results illustrated higher percentages of IL-4-, IL-10-, IL-21-, and IL-6-producing γδ T cells and lower percentages of IFN-γ-expressing γδ T cells in the lung of infected mice (<i>P</i> < 0.05). Moreover, the gran"],"journal":["Frontiers in immunology"],"pagination":["1045"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7287124"],"repository":["biostudies-literature"],"pubmed_title":["Adjustments of γδ T Cells in the Lung of <i>Schistosoma japonicum</i>-Infected C56BL/6 Mice."],"pmcid":["PMC7287124"],"pubmed_authors":["Qiu H","Cha H","Huang J","Wu Q","Feng Y","Xie S","Yin Z","Xie H","Jin C","Mu J","Qi Y","Yang Q","Xie A"],"additional_accession":[]},"is_claimable":false,"name":"Adjustments of γδ T Cells in the Lung of <i>Schistosoma japonicum</i>-Infected C56BL/6 Mice.","description":"Many kinds of lymphocytes are involved in <i>Schistosoma japonicum</i> (<i>S. japonicum</i>) infection-induced disease. γδ T cells comprise a small number of innate lymphocytes that quickly respond to foreign materials. In this study, the role of γδ T cells in the lung of <i>S. japonicum</i>-infected C56BL/6 mice was investigated. The results demonstrated that <i>S. japonicum</i> infection induces γδ T cell accumulation in the lung, expressing higher levels of CD25, MHCII, CD80, and PDL1, and lower levels of CD127 and CD62L (<i>P</i> < 0.05). The intracellular cytokines staining results illustrated higher percentages of IL-4-, IL-10-, IL-21-, and IL-6-producing γδ T cells and lower percentages of IFN-γ-expressing γδ T cells in the lung of infected mice (<i>P</i> < 0.05). Moreover, the gran","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-05-29T21:03:50.036Z","creation":"2025-05-29T21:03:50.036Z"},"accession":"S-EPMC7287124","cross_references":{"pubmed":["32582168"],"doi":["10.3389/fimmu.2020.01045"]}}