{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11"],"submitter":["Kannan N"],"funding":["Norges Forskningsråd","Helse Midt-Norge"],"pubmed_abstract":["<i>Mycobacterium avium</i> (Mav) complex is increasingly reported to cause non-tuberculous infections in individuals with a compromised immune system. Treatment is complicated and no vaccines are available. Previous studies have shown some potential of using genetically modified <i>Mycobacterium smegmatis</i> (Msm) as a vaccine vector to tuberculosis since it is non-pathogenic and thus would be tolerated by immunocompromised individuals. In this study, we used a mutant strain of Msm disrupted in EspG<sub>3</sub>, a component of the ESX-3 secretion system. Infection of macrophages and dendritic cells with Msm Δ<i>espG</i> <sub>3</sub> showed increased antigen presentation compared to cells infected with wild-type Msm. Vaccination of mice with Msm Δ<i>espG</i> <sub>3</sub>, expressing the Ma"],"journal":["Frontiers in immunology"],"pagination":["1116"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7296097"],"repository":["biostudies-literature"],"pubmed_title":["<i>Mycobacterium smegmatis</i> Vaccine Vector Elicits CD4+ Th17 and CD8+ Tc17 T Cells With Therapeutic Potential to Infections With <i>Mycobacterium avium</i>."],"pmcid":["PMC7296097"],"pubmed_authors":["Haug M","Flo TH","Kannan N","Steigedal M"],"additional_accession":[]},"is_claimable":false,"name":"<i>Mycobacterium smegmatis</i> Vaccine Vector Elicits CD4+ Th17 and CD8+ Tc17 T Cells With Therapeutic Potential to Infections With <i>Mycobacterium avium</i>.","description":"<i>Mycobacterium avium</i> (Mav) complex is increasingly reported to cause non-tuberculous infections in individuals with a compromised immune system. Treatment is complicated and no vaccines are available. Previous studies have shown some potential of using genetically modified <i>Mycobacterium smegmatis</i> (Msm) as a vaccine vector to tuberculosis since it is non-pathogenic and thus would be tolerated by immunocompromised individuals. In this study, we used a mutant strain of Msm disrupted in EspG<sub>3</sub>, a component of the ESX-3 secretion system. Infection of macrophages and dendritic cells with Msm Δ<i>espG</i> <sub>3</sub> showed increased antigen presentation compared to cells infected with wild-type Msm. Vaccination of mice with Msm Δ<i>espG</i> <sub>3</sub>, expressing the Ma","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-19T21:23:52.581Z","creation":"2020-07-01T07:08:32Z"},"accession":"S-EPMC7296097","cross_references":{"pubmed":["32582196"],"doi":["10.3389/fimmu.2020.01116"]}}