biostudies-literatureLee YKthe National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT &amp; Future Planning277-285https://www.ebi.ac.uk/biostudies/studies/S-EPMC7301394biostudies-literatureUnknown6(3)<h4>Objectives</h4>This study aims to investigate the effect of different occlusal relationships on skull structural and mechanical behaviors through simulation of chewing food.<h4>Methods</h4>Finite element (FE) skull models of occlusion for Class I, end-on Class II, and full-cusp Class II were generated. End-on Class II and full-cusp Class II were chosen as mild and severe Class II occlusions, respectively. A simplified food bolus was introduced between the upper and lower dentition of the right molars. Chewing food was simulated in the skulls by moving the mandible. An experiment was conducted to measure strains at selective locations and compared them to the analytical results for validation.<h4>Results</h4>In the early stages of mandibular movement, masticatory forces predicted from tClinical and experimental dental researchAn investigation into structural behaviors of skulls chewing food in different occlusal relationships using FEM.PMC7301394NRF-2017R1D1A1B03034274NRF-2014R1A1A1007583Chun YSLee YKfalseAn investigation into structural behaviors of skulls chewing food in different occlusal relationships using FEM.<h4>Objectives</h4>This study aims to investigate the effect of different occlusal relationships on skull structural and mechanical behaviors through simulation of chewing food.<h4>Methods</h4>Finite element (FE) skull models of occlusion for Class I, end-on Class II, and full-cusp Class II were generated. End-on Class II and full-cusp Class II were chosen as mild and severe Class II occlusions, respectively. A simplified food bolus was introduced between the upper and lower dentition of the right molars. Chewing food was simulated in the skulls by moving the mandible. An experiment was conducted to measure strains at selective locations and compared them to the analytical results for validation.<h4>Results</h4>In the early stages of mandibular movement, masticatory forces predicted from t2020-01-01T00:00:00Z2020 Jun2026-05-07T15:27:34.824Z2020-06-25T07:31:35ZS-EPMC73013943255831510.1002/cre2.273