{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gao C"],"funding":["National Natural Science Foundation of China","Tianjin Binhai New Area Health Commission Science-technology Innovation Plan Projects"],"pagination":["241"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7301524"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["<h4>Background</h4>Mesenchymal stem cells (MSCs) have become a promising candidate for cell-based immune therapy for acute rejection (AR) after heart transplantation due to possessing immunomodulatory properties. In this study, we evaluated the efficacy of soluble fibronectin-like protein 2 (sFgl2) overexpressing mesenchymal stem cells (sFgl2-MSCs) in inhibiting AR of heart transplantation in mice by regulating immune tolerance through inducing M2 phenotype macrophage polarization.<h4>Methods and results</h4>The sFgl2, a novel immunomodulatory factor secreted by regulatory T cells, was transfected into MSCs to enhance their immunosuppressive functions. After being co-cultured for 72 h, the sFgl2-MSCs inhibited M1 polarization whereas promoted M2 of polarization macrophages through STAT1 an"],"journal":["Stem cell research & therapy"],"pubmed_title":["Mesenchymal stem cells transfected with sFgl2 inhibit the acute rejection of heart transplantation in mice by regulating macrophage activation."],"pmcid":["PMC7301524"],"funding_grant_id":["2017BWKY036","81570375"],"pubmed_authors":["Liu Y","Li Z","Chen M","Lu J","Qi F","Jia H","Li P","Du X","Wang X","Chang Y","Zhang B","Gao C"],"additional_accession":[]},"is_claimable":false,"name":"Mesenchymal stem cells transfected with sFgl2 inhibit the acute rejection of heart transplantation in mice by regulating macrophage activation.","description":"<h4>Background</h4>Mesenchymal stem cells (MSCs) have become a promising candidate for cell-based immune therapy for acute rejection (AR) after heart transplantation due to possessing immunomodulatory properties. In this study, we evaluated the efficacy of soluble fibronectin-like protein 2 (sFgl2) overexpressing mesenchymal stem cells (sFgl2-MSCs) in inhibiting AR of heart transplantation in mice by regulating immune tolerance through inducing M2 phenotype macrophage polarization.<h4>Methods and results</h4>The sFgl2, a novel immunomodulatory factor secreted by regulatory T cells, was transfected into MSCs to enhance their immunosuppressive functions. After being co-cultured for 72 h, the sFgl2-MSCs inhibited M1 polarization whereas promoted M2 of polarization macrophages through STAT1 an","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2025-04-21T21:09:47.445Z","creation":"2020-06-25T07:31:39Z"},"accession":"S-EPMC7301524","cross_references":{"pubmed":["32552823"],"doi":["10.1186/s13287-020-01752-1"]}}