{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pyrih J"],"funding":["Grantová Agentura České Republiky","Agentúra na Podporu Výskumu a Vývoja","European Research Council","ERD funds","Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR"],"pagination":["e0234918"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7314023"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(6)"],"pubmed_abstract":["ZapE/Afg1 is a component of the inner cell membrane of some eubacteria and the inner mitochondrial membrane of eukaryotes. This protein is involved in FtsZ-dependent division of eubacteria. In the yeast and human mitochondrion, ZapE/Afg1 likely interacts with Oxa1 and facilitates the degradation of mitochondrion-encoded subunits of respiratory complexes. Furthermore, the depletion of ZapE increases resistance to apoptosis, decreases oxidative stress tolerance, and impacts mitochondrial protein homeostasis. It remains unclear whether ZapE is a multifunctional protein, or whether some of the described effects are just secondary phenotypes. Here, we have analyzed the functions of ZapE in Trypanosoma brucei, a parasitic protist, and an important model organism. Using a newly developed proximit"],"journal":["PloS one"],"pubmed_title":["ZapE/Afg1 interacts with Oxa1 and its depletion causes a multifaceted phenotype."],"pmcid":["PMC7314023"],"funding_grant_id":["LL1601","OPVVV 0000759","1/0387/17","18-18699S","APVV-0286-12","18-15962S"],"pubmed_authors":["Panek T","Pyrih J","Raskova V","Skodova-Sverakova I","Lukes J"],"additional_accession":[]},"is_claimable":false,"name":"ZapE/Afg1 interacts with Oxa1 and its depletion causes a multifaceted phenotype.","description":"ZapE/Afg1 is a component of the inner cell membrane of some eubacteria and the inner mitochondrial membrane of eukaryotes. This protein is involved in FtsZ-dependent division of eubacteria. In the yeast and human mitochondrion, ZapE/Afg1 likely interacts with Oxa1 and facilitates the degradation of mitochondrion-encoded subunits of respiratory complexes. Furthermore, the depletion of ZapE increases resistance to apoptosis, decreases oxidative stress tolerance, and impacts mitochondrial protein homeostasis. It remains unclear whether ZapE is a multifunctional protein, or whether some of the described effects are just secondary phenotypes. Here, we have analyzed the functions of ZapE in Trypanosoma brucei, a parasitic protist, and an important model organism. Using a newly developed proximit","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2026-05-02T18:30:22.176Z","creation":"2020-07-03T07:05:50Z"},"accession":"S-EPMC7314023","cross_references":{"pubmed":["32579605"],"doi":["10.1371/journal.pone.0234918"]}}