{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Haghani A"],"funding":["NIA NIH HHS"],"pubmed_abstract":["The neurotoxicity of air pollution is undefined for sex and <i>APOE</i> alleles. These major risk factors of Alzheimer's disease (AD) were examined in mice given chronic exposure to nPM, a nano-sized subfraction of urban air pollution. In the cerebral cortex, female mice had two-fold more genes responding to nPM than males. Transcriptomic responses to nPM had sex-<i>APOE</i> interactions in AD-relevant pathways. Only <i>APOE</i>3 mice responded to nPM in genes related to Abeta deposition and clearance (<i>Vav2</i>, <i>Vav3</i>, <i>S1009a</i>). Other responding genes included axonal guidance, inflammation (AMPK, NFKB, APK/JNK signaling), and antioxidant signaling (NRF2, HIF1A). Genes downstream of NFKB and NRF2 responded in opposite directions to nPM. <i>Nrf2</i> knockdown in microglia augmented NFKB responses to nPM, suggesting a critical role of NRF2 in air pollution neurotoxicity. These findings give a rationale for epidemiologic studies of air pollution to consider sex interactions with <i>APOE</i> alleles and other AD-risk genes."],"journal":["eLife"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7314548"],"repository":["biostudies-literature"],"pubmed_title":["Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and <i>APOE</i> in <i>Nrf2-Nfkb</i> interactions."],"pmcid":["PMC7314548"],"funding_grant_id":["R01AG051521","1RF1AG053982-01A1","T32 AG052374","4R00AG052604-02","P50AG05142","1R01AG057912-01","P01 AG055367","T32 AG000037"],"pubmed_authors":["Cacciottolo M","Levine ME","Zhang H","Morgan TE","Town TC","Finch CE","Thorwald M","D'Agostino C","Haghani A","Safi N","Forman HJ","Sioutas C","Doty KR"],"additional_accession":[]},"is_claimable":false,"name":"Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and <i>APOE</i> in <i>Nrf2-Nfkb</i> interactions.","description":"The neurotoxicity of air pollution is undefined for sex and <i>APOE</i> alleles. These major risk factors of Alzheimer's disease (AD) were examined in mice given chronic exposure to nPM, a nano-sized subfraction of urban air pollution. In the cerebral cortex, female mice had two-fold more genes responding to nPM than males. Transcriptomic responses to nPM had sex-<i>APOE</i> interactions in AD-relevant pathways. Only <i>APOE</i>3 mice responded to nPM in genes related to Abeta deposition and clearance (<i>Vav2</i>, <i>Vav3</i>, <i>S1009a</i>). Other responding genes included axonal guidance, inflammation (AMPK, NFKB, APK/JNK signaling), and antioxidant signaling (NRF2, HIF1A). Genes downstream of NFKB and NRF2 responded in opposite directions to nPM. <i>Nrf2</i> knockdown in microglia augmented NFKB responses to nPM, suggesting a critical role of NRF2 in air pollution neurotoxicity. These findings give a rationale for epidemiologic studies of air pollution to consider sex interactions with <i>APOE</i> alleles and other AD-risk genes.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Jun","modification":"2021-02-21T11:02:01Z","creation":"2020-07-01T07:06:25Z"},"accession":"S-EPMC7314548","cross_references":{"pubmed":["32579111"],"doi":["10.7554/eLife.54822"]}}