{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rose CM"],"funding":["National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["594-605"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7315617"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(2)"],"pubmed_abstract":["Triggered by Offset, Multiplexed, Accurate mass, High resolution, and Absolute Quantitation (TOMAHAQ) is a recently introduced targeted proteomics method that combines peptide and sample multiplexing. TOMAHAQ assays enable sensitive and accurate multiplexed quantification by implementing an intricate data collection scheme that comprises multiple MS<sup>n</sup> scans, mass inclusion lists, and data-driven filters. Consequently, manual creation of TOMAHAQ methods can be time-consuming and error prone, while the resulting TOMAHAQ data may not be compatible with common mass spectrometry analysis pipelines. To address these concerns we introduce TomahaqCompanion, an open-source desktop application that enables rapid creation of TOMAHAQ methods and analysis of TOMAHAQ data. Starting from a list"],"journal":["Journal of proteome research"],"pubmed_title":["TomahaqCompanion: A Tool for the Creation and Analysis of Isobaric Label Based Multiplexed Targeted Assays."],"pmcid":["PMC7315617"],"funding_grant_id":["GM67945","R01 GM067945"],"pubmed_authors":["Rose CM","Bomgarden R","Viner R","Gygi SP","Schweppe DK","Rogers J","Choi J","Kirkpatrick DS","Erickson BK"],"additional_accession":[]},"is_claimable":false,"name":"TomahaqCompanion: A Tool for the Creation and Analysis of Isobaric Label Based Multiplexed Targeted Assays.","description":"Triggered by Offset, Multiplexed, Accurate mass, High resolution, and Absolute Quantitation (TOMAHAQ) is a recently introduced targeted proteomics method that combines peptide and sample multiplexing. TOMAHAQ assays enable sensitive and accurate multiplexed quantification by implementing an intricate data collection scheme that comprises multiple MS<sup>n</sup> scans, mass inclusion lists, and data-driven filters. Consequently, manual creation of TOMAHAQ methods can be time-consuming and error prone, while the resulting TOMAHAQ data may not be compatible with common mass spectrometry analysis pipelines. To address these concerns we introduce TomahaqCompanion, an open-source desktop application that enables rapid creation of TOMAHAQ methods and analysis of TOMAHAQ data. Starting from a list","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2025-04-04T08:29:34.254Z","creation":"2020-07-01T07:06:59Z"},"accession":"S-EPMC7315617","cross_references":{"pubmed":["30501201"],"doi":["10.1021/acs.jproteome.8b00767"]}}