biostudies-literatureUnknown19(7)Wu YGalderma<h4>Background</h4>Patients are increasingly aware of the aesthetic appearance of aging hands.<h4>Aims</h4>To evaluate efficacy and safety of a hyaluronic acid gel for improving skin quality in aged skin of the dorsal hand.<h4>Methods</h4>This was a 15-month randomized, multi-center, evaluator-blinded, split-hand, no treatment-controlled study. Three treatments with hyaluronic acid gel were administered in the same hand in adult Chinese subjects with grade 2 or 3 (mild or moderate aging) on the Hand Grading Scale (HGS). The primary objective was to evaluate the difference at 3 months between treated and untreated hands, based on the blinded evaluator's HGS assessment. Secondary assessments included the Global Aesthetic Improvement Scale (GAIS), biophysical measurements (skin elasticity, skJournal of cosmetic dermatology1627-1635https://www.ebi.ac.uk/biostudies/studies/S-EPMC7318129biostudies-literatureA randomized study showing improved skin quality and aesthetic appearance of dorsal hands after hyaluronic acid gel treatment in a Chinese population.PMC7318129Zhong SWang RTian YWu WWu YXu JfalseA randomized study showing improved skin quality and aesthetic appearance of dorsal hands after hyaluronic acid gel treatment in a Chinese population.<h4>Background</h4>Patients are increasingly aware of the aesthetic appearance of aging hands.<h4>Aims</h4>To evaluate efficacy and safety of a hyaluronic acid gel for improving skin quality in aged skin of the dorsal hand.<h4>Methods</h4>This was a 15-month randomized, multi-center, evaluator-blinded, split-hand, no treatment-controlled study. Three treatments with hyaluronic acid gel were administered in the same hand in adult Chinese subjects with grade 2 or 3 (mild or moderate aging) on the Hand Grading Scale (HGS). The primary objective was to evaluate the difference at 3 months between treated and untreated hands, based on the blinded evaluator's HGS assessment. Secondary assessments included the Global Aesthetic Improvement Scale (GAIS), biophysical measurements (skin elasticity, sk2020-01-01T00:00:00Z2020 Jul2025-06-01T02:42:58.976Z2025-06-01T02:42:58.976ZS-EPMC73181293176959610.1111/jocd.13221