biostudies-literatureSama IENational Institute for Health Research (NIHR)821-833https://www.ebi.ac.uk/biostudies/studies/S-EPMC7319432biostudies-literatureUnknown22(5)<h4>Aims</h4>Heart failure (HF) is frequently caused by an ischaemic event (e.g. myocardial infarction) but might also be caused by a primary disease of the myocardium (cardiomyopathy). In order to identify targeted therapies specific for either ischaemic or non-ischaemic HF, it is important to better understand differences in underlying molecular mechanisms.<h4>Methods and results</h4>We performed a biological physical protein-protein interaction network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic HF. First, differentially expressed plasma protein biomarkers were identified in 1160 patients enrolled in the BIOSTAT-CHF study, 715 of whom had ischaemic HF and 445 had non-ischaemic HF. Second, we constructed an enriched physical protein-proteiEuropean journal of heart failureA network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure.PMC7319432NF-SI-0611-10170Nauta JFTer Maaten JMZannad FCleland JGFMetra Mvan der Meer PSama IEHillege HLLang CCSamani NJVoors AARomaine SPRDickstein KAnker SDLam CSPWoolley RJTromp JNg LLvan Veldhuisen DJfalseA network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic heart failure.<h4>Aims</h4>Heart failure (HF) is frequently caused by an ischaemic event (e.g. myocardial infarction) but might also be caused by a primary disease of the myocardium (cardiomyopathy). In order to identify targeted therapies specific for either ischaemic or non-ischaemic HF, it is important to better understand differences in underlying molecular mechanisms.<h4>Methods and results</h4>We performed a biological physical protein-protein interaction network analysis to identify pathophysiological pathways distinguishing ischaemic from non-ischaemic HF. First, differentially expressed plasma protein biomarkers were identified in 1160 patients enrolled in the BIOSTAT-CHF study, 715 of whom had ischaemic HF and 445 had non-ischaemic HF. Second, we constructed an enriched physical protein-protei2020-01-01T00:00:00Z2020 May2025-04-22T06:39:56.072Z2020-07-03T07:08:32ZS-EPMC73194323224369510.1002/ejhf.1811